概述

  • 产品名称Anti-Zic2抗体
    参阅全部 Zic2 一抗
  • 描述
    小鼠单克隆抗体to Zic2
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant tagged fragment (Human)

性能

应用

Our Abpromise guarantee covers the use of ab61278 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: Use at an assay dependent dilution.
    WB: Use at a concentration of 1 - 5 µg/ml. Predicted molecular weight: 55 kDa.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Acts as a transcriptional activator or repressor. Plays important roles in the early stage of organogenesis of the CNS. Activates the transcription of the serotonin transporter SERT in uncrossed ipsilateral retinal ganglion cells (iRGCs) to refine eye-specific projections in primary visual targets. Its transcriptional activity is repressed by MDFIC. Involved in the formation of the ipsilateral retinal projection at the optic chiasm midline. Drives the expression of EPHB1 on ipsilaterally projecting growth cones. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'. Associates to the basal SERT promoter region from ventrotemporal retinal segments of retinal embryos.
    • 疾病相关Defects in ZIC2 are a cause of holoprosencephaly type 5 (HPE5) [MIM:609637]. A structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. Although severe facial anomalies are common in HPE, patients with ZINC2 mutations have relatively normal faces.
    • 序列相似性Belongs to the GLI C2H2-type zinc-finger protein family.
      Contains 5 C2H2-type zinc fingers.
    • 结构域The C2H2-type 3, 4 and 5 zinc finger domains are necessary for transcription activation.
    • 翻译后修饰Phosphorylated.
      Ubiquitinated by RNF180, leading to its degradation.
    • 细胞定位Nucleus. Cytoplasm. Localizes in the cytoplasm in presence of MDFIC overexpression. Both phosphorylated and unphosphorylated forms are localized in the nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • HPE 5 antibody
      • HPE5 antibody
      • Odd paired homolog Drosophila antibody
      • Zic 2 antibody
      • Zic family member 2 (odd paired Drosophila homolog) antibody
      • Zic family member 2 antibody
      • ZIC2 antibody
      • ZIC2_HUMAN antibody
      • Zinc finger protein of the cerebellum 2 antibody
      • Zinc finger protein ZIC 2 antibody
      • Zinc finger protein Zic2 antibody
      see all

    Anti-Zic2 antibody 图像



    • Predicted band size : 55 kDa

    Anti-Zic2 antibody (ab61278)参考文献

    ab61278 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"