概述

  • 产品名称
  • 描述
    兔多克隆抗体to ZCCHV
  • 特异性
    ab105357 is predicted to not crossreact with other ZAP members. Four isoforms of ZCCHV are known to exist.
  • 经测试应用
    适用于: ICC/IF, WB, ICCmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A 14 amino acid synthetic peptide near the C terminus of Human ZCCHV (NP_078901).

  • 阳性对照
    • WB: HeLa cell lysate ICC: HeLa cells

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab105357 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 101 kDa.
ICC Use a concentration of 20 µg/ml.

靶标

  • 功能
    Induces an innate immunity to viral infections by preventing the accumulation of viral RNAs in the cytoplasm. Seems to recruit the RNA processing exosome to degrade the target RNAs. Inhibits alphavirus and filovirus replication.
  • 序列相似性
    Contains 4 C3H1-type zinc fingers.
    Contains 1 PARP catalytic domain.
    Contains 1 WWE domain.
  • 结构域
    The second and fourth zinc fingers are involved in binding to specific viral RNAs.
  • 细胞定位
    Cytoplasm. Nucleus. Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ADP ribosyltransferase diphtheria toxin like 13 antibody
    • ARTD13 antibody
    • FLB6421 antibody
    • PARP13 antibody
    • ZAP antibody
    • ZC3H2 antibody
    • ZC3HAV 1 antibody
    • Zc3hav1 antibody
    • ZC3HDC 2 antibody
    • ZC3HDC2 antibody
    • ZCCHV_HUMAN antibody
    • Zinc finger antiviral protein antibody
    • Zinc finger CCCH domain containing protein 2 antibody
    • Zinc finger CCCH domain-containing antiviral protein 1 antibody
    • Zinc finger CCCH domain-containing protein 2 antibody
    • Zinc finger CCCH type antiviral 1 antibody
    • Zinc finger CCCH type antiviral protein 1 antibody
    • Zinc finger CCCH-type antiviral protein 1 antibody
    see all

Anti-ZCCHV antibody 图像

  • Anti-ZCCHV antibody (ab105357) at 1 µg/ml + HeLa cell lysate at 15 µg

    Predicted band size : 101 kDa
  • Immunocytochemical analysis of ZCCHV in HeLa cells stained with ab105357 at 20 µg/ml.
  • Immunofluorescence of ZC3HAV1 in Hela cells using ab105357 at 20 ug/ml.

Anti-ZCCHV antibody (ab105357)参考文献

This product has been referenced in:
  • Lee H  et al. Zinc-finger antiviral protein mediates retinoic acid inducible gene I-like receptor-independent antiviral response to murine leukemia virus. Proc Natl Acad Sci U S A 110:12379-84 (2013). Read more (PubMed: 23836649) »

See 1 Publication for this product

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