概述

  • 产品名称Anti-ZC3H12D抗体
    参阅全部 ZC3H12D 一抗
  • 描述
    兔多克隆抗体to ZC3H12D
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    A 16 amino acid peptide from the intermediate residues of Human ZC3H12D protein (NP_997243).

  • 阳性对照
    • WB: Fetal small intestine lysate and fetal spleen lystae IHC-P: Fetal small intestine

性能

应用

Our Abpromise guarantee covers the use of ab100862 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 58 kDa.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能May regulate cell growth likely by suppressing RB1 phosphorylation (PubMed:19531561). May function as RNase and regulate the levels of target RNA species (Potential). In association with ZC3H12A enhances the degradation of interleukin IL-6 mRNA level in activated macrophages (PubMed:26134560). Serve as a tumor suppressor in certain leukemia cells (PubMed:17210687). Overexpression inhibits the G1 to S phase progression through suppression of RB1 phosphorylation (PubMed:19531561).
  • 组织特异性Expressed in normal human lymphocytes but defective in some leukemia/lymphoma cell lines.
  • 疾病相关A chromosomal aberration involving ZC3H12D may be the cause of the transformation of follicular lymphoma (FL) to diffuse large B-cell lymphoma (DLBCL). Translocation t(2;6)(p12;q25) with IGK. Resulting protein may not be expressed.
  • 序列相似性Belongs to the ZC3H12 family.
    Contains 1 C3H1-type zinc finger.
  • 细胞定位Cytoplasm. Nucleus; Cytoplasm. Localized as discrete granules. Colocalized with mRNA-processing body markers, AGO2 and DCP1A, but not with a stress granule maker, TIA1, in the cytoplasm and Cytoplasm, P-body. Colocalizes with ZC3H12A in GW bodies (GWBs) (PubMed:26134560).
  • Information by UniProt
  • 数据库链接
  • 别名
    • C6orf95 antibody
    • ZC3H12D antibody
    • FLJ00361 antibody
    • FLJ46041 antibody
    • MCP induced protein 4 antibody
    • MCP-induced protein 4 antibody
    • MCPIP4 antibody
    • p34 antibody
    • Probable ribonuclease ZC3H12D antibody
    • TFL antibody
    • Transformed follicular lymphoma antibody
    • Tumor suppressor TFL antibody
    • ZC12D_HUMAN antibody
    • ZC3H12D antibody
    • Zinc finger CCCH domain containing protein 12D antibody
    • Zinc finger CCCH domain-containing protein 12D antibody
    see all

Anti-ZC3H12D antibody 图像

  • All lanes : Anti-ZC3H12D antibody (ab100862) at 1/500 dilution

    Lane 1 : Human fetal small intestine lysate
    Lane 2 : Human fetal spleen lysate


    Predicted band size : 58 kDa
    Observed band size : 57 kDa (why is the actual band size different from the predicted?)
  • ab100862, at a 1/100 dilution, staining ZC3H12D in formalin-fixed, paraffin-embedded Human fetal small intestine tissue, showing cytoplasmic staining, by Immunohistochemistry.

Anti-ZC3H12D antibody (ab100862)参考文献

This product has been referenced in:
  • Huang S  et al. The putative tumor suppressor Zc3h12d modulates toll-like receptor signaling in macrophages. Cell Signal : (2011). IHC-P ; Mouse . Read more (PubMed: 22036805) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab100862.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"