Anti-ZAP70抗体[11H40] (ab69505)

概述

  • 产品名称Anti-ZAP70抗体[11H40]
    参阅全部 ZAP70 一抗
  • 描述
    小鼠单克隆抗体[11H40] to ZAP70
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Rat, Human
  • 免疫原

    Recombinant Human full length protein

  • 阳性对照
    • Human Jurkat cells and rat thymus

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab69505 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 70 kDa (predicted molecular weight: 70 kDa).

靶标

  • 功能Plays a role in T-cell development and lymphocyte activation. Essential for TCR-mediated IL-2 production. Isoform 1 induces TCR-mediated signal transduction, isoform 2 does not.
  • 组织特异性Expressed in T- and natural killer cells.
  • 疾病相关Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.
  • 序列相似性Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily.
    Contains 1 protein kinase domain.
    Contains 2 SH2 domains.
  • 结构域The SH2 domains bind to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z and the non-canonical phosphorylated tyrosine-based activation motif (TAM) of RHOH.
  • 翻译后修饰Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319 phosphorylation is essential for full activity.
  • 细胞定位Cytoplasm. Cell membrane. After antigen stimulation, isoform 1 concentrates at the immunological synapse and isoform 2 remains cytoplasmic. Co-localizes together with RHOH in the immunological synapse. RHOH is required for its proper localization to the cell membrane and cytoskeleton fractions in the thymocytes.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 70 kDa zeta associated protein antibody
    • 70 kDa zeta-associated protein antibody
    • EC 2.7.10.2 antibody
    • FLJ17670 antibody
    • FLJ17679 antibody
    • Selective T cell defect antibody
    • SRK antibody
    • STD antibody
    • Syk related tyrosine kinase antibody
    • Syk-related tyrosine kinase antibody
    • Truncated ZAP kinase antibody
    • Tyrosine protein kinase ZAP70 antibody
    • Tyrosine-protein kinase ZAP-70 antibody
    • TZK antibody
    • ZAP 70 antibody
    • ZAP70 antibody
    • ZAP70_HUMAN antibody
    • Zeta chain associated protein kinase 70kD antibody
    • Zeta chain associated protein kinase 70kDa antibody
    • Zeta chain associated protein kinase 70kDa isoform 1 antibody
    • Zeta chain associated protein kinase 70kDa isoform 2 antibody
    • Zeta chain TCR associated protein kinase 70kD antibody
    • Zeta chain TCR associated protein kinase 70kDa antibody
    see all

Anti-ZAP70 antibody [11H40] 图像

  • All lanes : Anti-ZAP70 antibody [11H40] (ab69505) at 1 µg/ml

    Lane 1 : MW marker
    Lane 2 : Jurkat cell lysate
    Lane 3 : Rat thymus lysate
    Lane 4 : Human recombinant GST-tagged ZAP70

    Developed using the ECL technique

    Predicted band size : 70 kDa
    Observed band size : 70 kDa

Anti-ZAP70 antibody [11H40] (ab69505)参考文献

ab69505 has not yet been referenced specifically in any publications.

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