Anti-ZAK抗体(ab57318)

概述

  • 产品名称Anti-ZAK抗体
    参阅全部 ZAK 一抗
  • 描述
    小鼠单克隆抗体to ZAK
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-456 of Human ZAK (isoform 2 of Q9NYL2)

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 同种型IgG2b
  • 轻链类型kappa
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab57318 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2. Isoform 1, but not isoform 2, causes cell shrinkage and disruption of actin stress fibers. Isoform 1 may have role in neoplastic cell transformation and cancer development. Isoform 1, but not isoform 2, phosphorylates histone H3 at 'Ser-28'.
    • 组织特异性Ubiquitously expressed. Isoform 2 is the predominant form in all tissues examined, except for liver, in which isoform 1 is more highly expressed.
    • 序列相似性Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
      Contains 1 protein kinase domain.
      Contains 1 SAM (sterile alpha motif) domain.
    • 细胞定位Cytoplasm. Nucleus. Translocates to the nucleus upon ultraviolet B irradiation.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AZK antibody
      • Cervical cancer suppressor gene 4 protein antibody
      • HCCS 4 antibody
      • HCCS-4 antibody
      • HCCS4 antibody
      • Human cervical cancer suppressor gene 4 protein antibody
      • Leucine zipper and sterile alpha motif containing kinase antibody
      • Leucine zipper- and sterile alpha motif-containing kinase antibody
      • Mitogen activated protein kinase kinase kinase MLT antibody
      • Mitogen-activated protein kinase kinase kinase MLT antibody
      • Mixed lineage kinase 7 antibody
      • Mixed lineage kinase related kinase antibody
      • Mixed lineage kinase related kinase MRK beta antibody
      • Mixed lineage kinase with a leucine zipper and a sterile alpha motif antibody
      • Mixed lineage kinase-related kinase antibody
      • MLK 7 antibody
      • MLK like mitogen activated protein triple kinase antibody
      • MLK related kinase antibody
      • MLK-like mitogen-activated protein triple kinase antibody
      • MLK-related kinase antibody
      • MLK7 antibody
      • Mlklak antibody
      • MLT antibody
      • MLTK_HUMAN antibody
      • MRK antibody
      • Sterile alpha motif and leucine zipper containing kinase AZK antibody
      • Sterile alpha motif- and leucine zipper-containing kinase AZK antibody
      • Zak antibody
      see all

    Anti-ZAK antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab57318 ZAK antibody at 1ug/ml. Predicted band size of immunogen is 76 kDa

    Anti-ZAK antibody (ab57318)参考文献

    ab57318 has not yet been referenced specifically in any publications.

    Product Wall

    Merci de nous avoir contactés.

    Après vérification auprès du laboratoire, je vous confirme que l'anti-ZAK ab57318a été produit en utilisant l'isoforme 2 (ou la forme beta) de la ZAK humaine dont la s&ea...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"