(Z)-4-Hydroxytamoxifen,estrogen receptor modulator (ab141943)
Key features and details
- Potent and selective estrogen receptor modulator
- CAS Number: 68047-06-3
- Purity: > 98%
- Soluble in ethanol to 50 mM and in DMSO to 100 mM
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
(Z)-4-Hydroxytamoxifen,estrogen receptor modulator -
描述
Potent and selective estrogen receptor modulator -
别名
- 4-OHT
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纯度
> 98% -
CAS编号
68047-06-3 -
化学结构
性能
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化学名称
4-[(Z)-1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol -
分子量
387.52 -
分子式
C26H29NO2 -
PubChem识别号
449459 -
存放说明
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in ethanol to 50 mM and in DMSO to 100 mM -
处理
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CCC(=C(C1=CC=C(C=C1)O)C2=CC=C(C=C2)OCCN(C)C)C3=CC=CC=C3 -
来源
Synthetic
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研究领域
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (10)
ab141943 被引用在 10 文献中.
- Igarashi T et al. An ATR-PrimPol pathway confers tolerance to oncogenic KRAS-induced and heterochromatin-associated replication stress. Nat Commun 14:4991 (2023). PubMed: 37591859
- Yoshida K et al. Microscopic Detection of DNA Synthesis in Early Mitosis at Repetitive lacO Sequences in Human Cells. Bio Protoc 12:N/A (2022). PubMed: 36213106
- Sula A et al. A tamoxifen receptor within a voltage-gated sodium channel. Mol Cell 81:1160-1169.e5 (2021). PubMed: 33503406
- Zink J et al. EVL regulates VEGF receptor-2 internalization and signaling in developmental angiogenesis. EMBO Rep 22:e48961 (2021). PubMed: 33512764
- Crawford M et al. Integrin-linked kinase regulates melanosome trafficking and melanin transfer in melanocytes. Mol Biol Cell 31:768-781 (2020). PubMed: 32049584
- Kyprianou C et al. Basement membrane remodelling regulates mouse embryogenesis. Nature 582:253-258 (2020). PubMed: 32523119
- Crawford M et al. Essential Role for Integrin-Linked Kinase in Melanoblast Colonization of the Skin. J Invest Dermatol N/A:N/A (2019). PubMed: 31330146
- Bartels M et al. Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression. Sci Rep 9:9100 (2019). PubMed: 31235814
- Itkonen HM et al. High OGT activity is essential for MYC-driven proliferation of prostate cancer cells. Theranostics 9:2183-2197 (2019). PubMed: 31149037
- Hatzistergos KE et al. cKit+ cardiac progenitors of neural crest origin. Proc Natl Acad Sci U S A 112:13051-6 (2015). PubMed: 26438843