概述

  • 产品名称
    YM298198 hydrochloride
  • 描述
    Potent, selective mGlu1 antagonist
  • 生物学描述
    Potent, selective, water-soluble, non-competitive mGlu1 antagonist (IC50 = 16 nM) Selective over mGlu2,3,4,5,6, and 7 and ionotropic receptors (IC50 > 10 μM). Orally active analgesic in vivo.

    Also available in simple stock solutions (ab146667) - add 1 ml of water to get an exact, ready-to-use concentration.
  • 纯度
    > 99%

性能

文献

This product has been referenced in:
  • Knöpfel T Two new non-competitive mGlu1 receptor antagonists are potent tools to unravel functions of this mGlu receptor subtype. Br J Pharmacol 151:723-4 (2007). Read more (PubMed: 17502846) »
  • Fukunaga I  et al. Potent and specific action of the mGlu1 antagonists YM-298198 and JNJ16259685 on synaptic transmission in rat cerebellar slices. Br J Pharmacol 151:870-6 (2007). Read more (PubMed: 17502847) »
  • Kohara A  et al. Radioligand binding properties and pharmacological characterization of 6-amino-N-cyclohexyl-N,3-dimethylthiazolo[3,2-a]benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective, and noncompetitive antagonist of metabotropic glutamate receptor type 1. J Pharmacol Exp Ther 315:163-9 (2005). Read more (PubMed: 15976016) »

See all 4 Publications for this product

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