Y-27632 dihydrochloride (mM/ml),Rho kinase抑制剂(ab144494)
Key features and details
- Selective Rho kinase inhibitor. 1 ml water soluble pack.
- CAS Number: 129830-38-2
- Purity: > 99%
- Soluble in 1 of ml water to give specified mM/ml concentration
- Form / State: Solid
- Source: Synthetic
概述
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产品名称
Y-27632 dihydrochloride (mM/ml),Rho kinase抑制剂 -
描述
Selective Rho kinase抑制剂. 1 ml water soluble pack. -
生物学描述
Selective Rho kinase inhibitor.
Soluble in 1 ml water to give specified mM/ml concentration. Find out more. -
纯度
> 99% -
CAS编号
129830-38-2 -
化学结构
性能
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化学名称
(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochloride -
分子量
320.26 -
分子式
C14H21N3O.2HCl -
PubChem识别号
9901617 -
存放说明
Store at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
溶解度概述
Soluble in 1 of ml water to give specified mM/ml concentration -
处理
This product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.Cl.O=C(Nc1ccncc1)[C@@H]2CC[C@H](CC2)[C@@H](C)N -
来源
Synthetic
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研究领域
图片
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2D chemical structure image of ab144494, Y-27632 dihydrochloride (mM/ml), Rho kinase inhibitor
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Representative morphology and membrane potential responses to current step injection in hESMNs at 3 different times in vitro.
Imaging of cells fixed after patch-clamp recordings indicate that recorded cells express the Hb9::GFP reporter transgene (A-C,E,G,and I). Voltage responses and imaging in the same rows are taken from same neurons. The neurons for A-C are same as that shown in F and G. D,F,H show examples of voltage responses to current steps recorded from 3 neurons current-clamped at −58 mV, −60 mV, and −55 mV, respectively. Bottom traces in D,F, and H show injected currents. Scale bars in images are 50 μm.
Only part of full image panel shown.
Cells were pre-treated with ab144494.
实验方案
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
文献 (13)
ab144494 被引用在 13 文献中.
- Paknikar AK et al. Direct characterization of cytoskeletal reorganization during blood platelet spreading. Prog Biophys Mol Biol N/A:N/A (2018). PubMed: 29843920
- Amoroso MW et al. Accelerated high-yield generation of limb-innervating motor neurons from human stem cells. J Neurosci 33:574-86 (2013). PubMed: 23303937
- Fujii M et al. Inhibition of Rho kinase by hydroxyfasudil attenuates brain edema after subarachnoid hemorrhage in rats. Neurochem Int 60:327-33 (2012). PubMed: 22226843
- Katz SF et al. Disruption of Trp53 in livers of mice induces formation of carcinomas with bilineal differentiation. Gastroenterology 142:1229-1239.e3 (2012). PubMed: 22342966
- Chen TH et al. Patterns of periodic holes created by increased cell motility. Interface Focus 2:457-64 (2012). PubMed: 22649581