概述

  • 产品名称Anti-XRN2抗体
    参阅全部 XRN2 一抗
  • 描述
    兔多克隆抗体to XRN2
  • 经测试应用适用于: IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Chimpanzee, Rhesus monkey, Orangutan, Bat, Elephant
  • 免疫原

    Synthetic peptide corresponding to a region between residues 900 and 950 human XRN2 (NP_036387.2).

  • 阳性对照
    • Human tissues: Breast Carcinoma, Colon Carcinoma, Linitis Plastica Stomach Cancer, Non Small Cell Lung Cancer, Ovarian Carcinoma, Pancreatic Islet Cell Tumor, Prostate Carcinoma, Skin Basal Cell Carcinoma, Small Cell Lung Cancer, Stomach Adenocarcinoma, Testicular Seminoma. Mouse tissues: Colon Carcinoma CT26, Teratoma.

性能

应用

Our Abpromise guarantee covers the use of ab74408 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
ICC/IF
  • 应用说明ICC/IF: 1/100.
    IHC-P: 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.
    ab74408 is likely to work with frozen sections.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性XRN2 possesses 5'->3' exoribonuclease activity. XRN2 shares similarity with the mouse Dhm1 and the yeast dhp1 gene. The function of the human gene has not yet been determined, however, it may promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription.
    • 细胞定位Nucleus, nucleolus.
    • 数据库链接
    • 别名
      • 5' 3' exoribonuclease 2 antibody
      • DHM1 like protein antibody
      • DHP protein antibody
      • XRN 2 antibody

    Anti-XRN2 antibody 图像

    • ab74408, at 1/250 dilution, staining XRN2 in formalin fixed, paraffin embedded human breast carcinoma tissue by Immunohistochemistry. Detection: DAB staining.
    • ab74408, at 1/250 dilution, staining XRN2 in formalin fixed, paraffin embedded human ovarian carcinoma tissue by Immunohistochemistry. Detection: DAB staining.
    • ab74408, at 1/250 dilution, staining XRN2 in formalin fixed, paraffin embedded mouse teratoma tissue by Immunohistochemistry. Detection: DAB staining.
    • ab74408, at 1/100 dilution, staining XRN2 in human breast carcinoma tissue by Immunofluorescence. Detection: Red fluorescent Alexa Fluor 555 goat anti rabbit IgG at 1/500.

    Anti-XRN2 antibody (ab74408)参考文献

    ab74408 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"