概述

  • 产品名称Anti-XRCC1抗体
    参阅全部 XRCC1 一抗
  • 描述
    兔多克隆抗体to XRCC1
  • 特异性ab58465 detects endogenous levels of total XRCC1 protein.
  • 经测试应用适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide derived from internal sequence of human XRCC1.

  • 阳性对照
    • WB: Extracts from Jurkat cells. IHC-P: human lung carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab58465 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 70 kDa (predicted molecular weight: 70 kDa).
IHC-P Use at an assay dependent concentration.
ELISA 1/10000.

靶标

  • 功能Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.
  • 序列相似性Contains 2 BRCT domains.
  • 翻译后修饰Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.
    Sumoylated.
  • 细胞定位Nucleus. Accumulates at sites of DNA damage.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DNA repair protein XRCC1 antibody
    • RCC antibody
    • X ray repair complementing defective repair in chinese hamster antibody
    • X ray Repair Complementing Defective Repair in Chinese Hamster Cells antibody
    • X ray repair complementing defective repair in chinese hamster cells 1 antibody
    • X ray repair cross complementing 1 antibody
    • X ray repair cross complementing protein 1 antibody
    • X ray repair, complementing defective, repair in Chinese hamster antibody
    • X-ray repair cross-complementing protein 1 antibody
    • XRCC 1 antibody
    • Xrcc1 antibody
    • XRCC1_HUMAN antibody
    see all

Anti-XRCC1 antibody 图像

  • All lanes : Anti-XRCC1 antibody (ab58465) at 1/500 dilution

    Lane 1 : Extracts from Jurkat cells
    Lane 2 : Extracts from Jurkat cells with immunizing peptide


    Predicted band size : 70 kDa
    Observed band size : 70 kDa
  • Ab58465, at 1/50 dilution, staining paraffin embedded human lung carcinoma tissue by Immunohistochemistry in the absence (left image) or presence (right image) of the immunising peptide.

Anti-XRCC1 antibody (ab58465)参考文献

ab58465 has not yet been referenced specifically in any publications.

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