概述

  • 产品名称Anti-XPNPEP3抗体
    参阅全部 XPNPEP3 一抗
  • 描述
    兔多克隆抗体to XPNPEP3
  • 经测试应用适用于: WB, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant protein fragment containing a sequence corresponding to a region within amino acids 12 and 482 of XPNPEP3 (NP_071381).

  • 阳性对照
    • WB: A431 whole cell lysate; 293T, H1299, HepG2, MOLT4 and Raji cell lysates ICC/IF: A549 cells

性能

应用

Our Abpromise guarantee covers the use of ab95982 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 57 kDa.
ICC/IF 1/100 - 1/200.

靶标

  • 组织特异性Isoform 1 and isoform 2 are widely expressed, with isoform 1 being more abundant.
  • 疾病相关Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 (NPHPL1) [MIM:613159]. A disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure. Nephronophthisis is histologically characterized by modifications of the tubules with thickening of the basement membrane, interstitial fibrosis and, in the advanced stages, medullary cysts. Typical clinical manifestation are chronic renal failure, anemia, polyuria, polydipsia, isosthenuria, and growth retardation. Associations with extrarenal symptoms are frequent. In NPHPL1 patients, extrarenal symptoms include hypertension, essential tremor, sensorineural hearing loss and gout. Severely affected individuals can manifest a mitochondrial disorder with isolated complex I deficiency activity in muscle, seizures, mental retardation and hypertrophic dilated cardiomyopathy.
  • 序列相似性Belongs to the peptidase M24B family.
  • 细胞定位Mitochondrion.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Aminopeptidase P3 antibody
    • APP3 antibody
    • NPHPL1 antibody
    • OTTHUMP00000199806 antibody
    • Probable Xaa Pro aminopeptidase 3 antibody
    • Probable Xaa-Pro aminopeptidase 3 antibody
    • X Pro aminopeptidase 3 antibody
    • X prolyl aminopeptidase (aminopeptidase P) 3 antibody
    • X-Pro aminopeptidase 3 antibody
    • XPNPEP3 antibody
    • XPP3_HUMAN antibody
    see all

Anti-XPNPEP3 antibody 图像

  • Anti-XPNPEP3 antibody (ab95982) at 1/500 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 57 kDa
  • Immunofluorescence analysis of XPNPEP3 in paraformaldehyde fixed A549, using ab95982 at 1/200 dilution. Lower image merged with DNA probe.

Anti-XPNPEP3 antibody (ab95982)参考文献

ab95982 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab95982.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"