概述

  • 产品名称Anti-XPG抗体
    参阅全部 XPG 一抗
  • 描述
    兔多克隆抗体to XPG
  • 经测试应用适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Gorilla
  • 免疫原

    Synthetic peptide, corresponding to a region within amino acids 650-700 of Human XPG (NP_000114.2).

  • 阳性对照
    • Human Anaplastic Thyroid Carcinoma, Human Breast Carcinoma, Human Linitis Plastica Stomach Cancer, Human Ovarian Carcinoma, Human Pancreatic Islet Cell Tumor, Human Skin Basal Cell Carcinoma

性能

应用

Our Abpromise guarantee covers the use of ab99248 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/100 - 1/500.

靶标

  • 功能Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.
  • 疾病相关Defects in ERCC5 are the cause of xeroderma pigmentosum complementation group G (XP-G) [MIM:278780]; also known as xeroderma pigmentosum VII (XP7). Xeroderma pigmentosum is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Some XP-G patients present features of Cockayne syndrome, including dwarfism, sensorineural deafness, microcephaly, mental retardation, pigmentary retinopathy, ataxia, decreased nerve conduction velocities.
  • 序列相似性Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • COFS 3 antibody
    • COFS3 antibody
    • DNA excision repair protein ERCC 5 antibody
    • DNA excision repair protein ERCC-5 antibody
    • DNA excision repair protein ERCC5 antibody
    • DNA repair protein complementing XP G cells antibody
    • DNA repair protein complementing XP-G cells antibody
    • DNA repair protein complementing XPG cells antibody
    • ERCC 5 antibody
    • ERCC5 antibody
    • ERCC5_HUMAN antibody
    • ERCM 2 antibody
    • ERCM2 antibody
    • Excision repair cross complementation group 5 antibody
    • Excision Repair Cross Complementing Rodent Repair Deficiency antibody
    • Excision repair cross complementing rodent repair deficiency complementation group 5 antibody
    • Excision repair protein antibody
    • OTTHUMP00000064902 antibody
    • UVDR antibody
    • Xeroderma Pigmentosum Complementation Group G antibody
    • Xeroderma pigmentosum complementation group G protein antibody
    • Xeroderma pigmentosum group G complementing protein antibody
    • Xeroderma pigmentosum group G-complementing protein antibody
    • XPG antibody
    • XPG complementing protein antibody
    • XPGC antibody
    see all

Anti-XPG antibody 图像

  • Staining of XPG in a Formalin/PFA-fixed paraffin-embedded sections of Human Ovarian Carcinoma using ab99248 at a dilution of 1/250. Detection: DAB staining.

Anti-XPG antibody (ab99248)参考文献

This product has been referenced in:
  • Deng N  et al. Expression of XPG Protein in the Development, Progression and Prognosis of Gastric Cancer. PLoS One 9:e108704 (2014). IHC-P ; Human . Read more (PubMed: 25268735) »

See 1 Publication for this product

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