功能Single-stranded structure-specific DNA endonuclease involved in DNA excision repair. Makes the 3'incision in DNA nucleotide excision repair (NER). Acts as a cofactor for a DNA glycosylase that removes oxidized pyrimidines from DNA. May also be involved in transcription-coupled repair of this kind of damage, in transcription by RNA polymerase II, and perhaps in other processes too.
疾病相关Defects in ERCC5 are the cause of xeroderma pigmentosum complementation group G (XP-G) [MIM:278780]; also known as xeroderma pigmentosum VII (XP7). Xeroderma pigmentosum is an autosomal recessive pigmentary skin disorder characterized by solar hypersensitivity of the skin, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Some XP-G patients present features of Cockayne syndrome, including dwarfism, sensorineural deafness, microcephaly, mental retardation, pigmentary retinopathy, ataxia, decreased nerve conduction velocities.
序列相似性Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.
Xeroderma Pigmentosum Complementation Group G antibody
Xeroderma pigmentosum complementation group G protein antibody
Xeroderma pigmentosum group G complementing protein antibody
Xeroderma pigmentosum group G-complementing protein antibody
XPG complementing protein antibody
Anti-XPG antibody [8H7] (ab46)参考文献
This product has been referenced in:
Trego KS et al. The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome. Cell Cycle10:1998-2007 (2011).
Read more (PubMed: 21558802) »
Igoucheva O et al. Involvement of ERCC1/XPF and XPG in oligodeoxynucleotide-directed gene modification. Oligonucleotides16:94-104 (2006).
Read more (PubMed: 16584298) »