概述

  • 产品名称
  • 描述
    兔多克隆抗体to XPF
  • 经测试应用
    适用于: IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide, corresponding to a region between residues 855 and 905 of human XPF (AAB07689.1)

  • 阳性对照
    • Human Breast Carcinoma and Prostate Carcinoma tissues.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.09% Sodium Azide
    Constituents: 0.1% BSA, Tris buffered saline
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab84540 was affinity purified using an epitope specific to XPF immobilized on solid support.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab84540 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
  • 应用说明
    IHC-P: 1/100 - 1/500.
    Epitope exposure with citrate buffer will enhance staining and is recommended

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Structure-specific DNA repair endonuclease responsible for the 5-prime incision during DNA repair. Involved in homologous recombination that assists in removing interstrand cross-link.
    • 疾病相关
      Defects in ERCC4 are the cause of xeroderma pigmentosum complementation group F (XP-F) [MIM:278760]; also known as xeroderma pigmentosum VI (XP6). XP-F is an autosomal recessive disease characterized by hypersensitivity of the skin to sunlight followed by high incidence of skin cancer and frequent neurologic abnormalities.
      Defects in ERCC4 are a cause of XFE progeroid syndrome (XFEPS) [MIM:610965]. This syndrome is illustrated by one patient who presented with dwarfism, cachexia and microcephaly.
    • 序列相似性
      Belongs to the XPF family.
      Contains 1 ERCC4 domain.
    • 细胞定位
      Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DNA excision repair protein ERCC 4 antibody
      • DNA excision repair protein ERCC-4 antibody
      • DNA excision repair protein ERCC4 antibody
      • DNA repair endonuclease XPF antibody
      • DNA repair protein complementing XP F cells antibody
      • DNA repair protein complementing XP-F cells antibody
      • ERCC 11 antibody
      • ERCC 4 antibody
      • ERCC11 antibody
      • ERCC4 antibody
      • Excision repair complementing defective in Chinese hamster antibody
      • Excision repair cross complementing rodent repair deficiency complementation group 4 antibody
      • excision repair cross-complementation group 4 antibody
      • FANCQ antibody
      • RAD 1 antibody
      • RAD1 antibody
      • Xeroderma pigmentosum complementation group F antibody
      • Xeroderma pigmentosum group F complementing protein antibody
      • Xeroderma pigmentosum group F-complementing protein antibody
      • Xeroderma pigmentosum VI antibody
      • XP, group G antibody
      • XP6 antibody
      • XPF_HUMAN antibody
      see all

    图片

    • ab84540 at 1/500 dilution staining XPF in human prostate carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    文献

    ab84540 has not yet been referenced specifically in any publications.

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    There are currently no Customer reviews or Questions for ab84540.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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