Anti-XPA抗体(ab10905)

概述

  • 产品名称Anti-XPA抗体
    参阅全部 XPA 一抗
  • 描述
    兔多克隆抗体to XPA
  • 特异性Ab10905 recognises both normal and recombinant XPA, and shows no cross reactivity with other XP proteins.
  • 经测试应用适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein (Human).

性能

应用

Our Abpromise guarantee covers the use of ab10905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
WB
  • 应用说明IHC-P: 1:50. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. Use of antigen unmasking fluid for this purpose is recommended. A two hour incubation with Ab10905 is recommended.
    WB: 1/5000. Detects a band of approximately 40-42 kDa doubled (predicted molecular weight: 32.8 kDa).

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
    • 组织特异性Expressed in various cell lines and in skin fibroblasts.
    • 疾病相关Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A) [MIM:278700]; also known as xeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.
    • 序列相似性Belongs to the XPA family.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
      Ubiquitinated by HERC2 leading to degradation by the proteasome.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • DNA repair protein complementing XP A cells antibody
      • DNA repair protein complementing XP-A cells antibody
      • DNA repair protein complementing XPA cells antibody
      • Excision repair controlling antibody
      • Xeroderma pigmentosum 1 antibody
      • Xeroderma pigmentosum complementation group A antibody
      • Xeroderma pigmentosum group A complementing protein antibody
      • Xeroderma pigmentosum group A-complementing protein antibody
      • XP 1 antibody
      • XP1 antibody
      • xpa antibody
      • XPA_HUMAN antibody
      • Xpac antibody
      see all

    Anti-XPA antibody (ab10905)参考文献

    ab10905 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry. We have several antibodies against this target: ab10905, ab2352, ab44, ab20252, ab23928, ab7289 and ab21085. If the epitope(s) have been mapped, this information is added on the product datasheet. Most of the time these d...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"