The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.
功能Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
组织特异性Expressed in various cell lines and in skin fibroblasts.
疾病相关Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A) [MIM:278700]; also known as xeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.
序列相似性Belongs to the XPA family.
翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR. Ubiquitinated by HERC2 leading to degradation by the proteasome.
DNA repair protein complementing XP A cells antibody
DNA repair protein complementing XP-A cells antibody
DNA repair protein complementing XPA cells antibody
Excision repair controlling antibody
Xeroderma pigmentosum 1 antibody
Xeroderma pigmentosum complementation group A antibody
Xeroderma pigmentosum group A complementing protein antibody
Xeroderma pigmentosum group A-complementing protein antibody
XP 1 antibody
Anti-XPA antibody [5A2] (ab44)参考文献
This product has been referenced in:
Wei Q et al. Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck. Cancer Epidemiol Biomarkers Prev14:1961-6 (2005).
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