概述

  • 产品名称Anti-XPA抗体[5A2]
    参阅全部 XPA 一抗
  • 描述
    小鼠单克隆抗体[5A2] to XPA
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    His-tagged recombinant human XPA (Xeroderma Pigmentosum group A) protein

  • 常规说明Works on pure and partially purified protein but not on crude cell extract.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Phosphate buffered saline
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆单克隆
  • 克隆编号5A2
  • 骨髓瘤Sp2
  • 同种型IgG1
  • 轻链类型unknown
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab44 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent dilution. Predicted molecular weight: 31 kDa.

靶标

  • 功能Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region. Required for UV-induced CHK1 phosphorylation and the recruitment of CEP164 to cyclobutane pyrimidine dimmers (CPD), sites of DNA damage after UV irradiation.
  • 组织特异性Expressed in various cell lines and in skin fibroblasts.
  • 疾病相关Defects in XPA are a cause of xeroderma pigmentosum complementation group A (XP-A) [MIM:278700]; also known as xeroderma pigmentosum type 1 (XP1). XP-A is a rare human autosomal recessive disease characterized by solar sensitivity, high predisposition for developing cancers on areas exposed to sunlight and, in some cases, neurological abnormalities. Group A patients show the most severe skin symptoms and progressive neurological disorders.
  • 序列相似性Belongs to the XPA family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    Ubiquitinated by HERC2 leading to degradation by the proteasome.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • DNA repair protein complementing XP A cells antibody
    • DNA repair protein complementing XP-A cells antibody
    • DNA repair protein complementing XPA cells antibody
    • Excision repair controlling antibody
    • Xeroderma pigmentosum 1 antibody
    • Xeroderma pigmentosum complementation group A antibody
    • Xeroderma pigmentosum group A complementing protein antibody
    • Xeroderma pigmentosum group A-complementing protein antibody
    • XP 1 antibody
    • XP1 antibody
    • xpa antibody
    • XPA_HUMAN antibody
    • Xpac antibody
    see all

Anti-XPA antibody [5A2] (ab44)参考文献

This product has been referenced in:
  • Wei Q  et al. Expression of nucleotide excision repair proteins in lymphocytes as a marker of susceptibility to squamous cell carcinomas of the head and neck. Cancer Epidemiol Biomarkers Prev 14:1961-6 (2005). Read more (PubMed: 16103444) »

See 1 Publication for this product

Product Wall

Thank you for your enquiry regarding ab44. We have not mapped the epitope recognized by this antibody therefore we do not know if it will or will not recognized your truncated protein. All our other antibodies against XPA are likely to recognize the no...

Read More

Thank you for your enquiry. All the information that we have regarding this antibody is located on the online datasheet, and at this time, we are unaware of any publications/references that feature the use of ab44. If you have any more questions, pleas...

Read More

Thank you for getting back to us and sharing your recent results. We are very sorry to hear that you are still having problem with this antibody. The protocol we have sent it to you is a general ELISA method. Looking at our order record, we can ...

Read More

Thank you for your enquiry. We are very sorry to hear that you are having problem with this product. I have searched our database and found that this is a popular selling product and your feedback is the first we have received about it not working....

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"