Anti-XIAP抗体- N-terminal (ab86229)

概述

  • 产品名称Anti-XIAP抗体- N-terminal
    参阅全部 XIAP 一抗
  • 描述
    兔多克隆抗体to XIAP - N-terminal
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide selected from the N-terminal region of Human XIAP conjugated to KLH (NP_001158).

  • 阳性对照
    • Mouse liver tissue and Ramos cell line lysates.

性能

应用

Our Abpromise guarantee covers the use of ab86229 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 57 kDa.
IHC-P 1/50 - 1/100.

靶标

  • 功能Apoptotic suppressor. Has E3 ubiquitin-protein ligase activity. Mediates the proteasomal degradation of target proteins, such as caspase-3, SMAC or AIFM1. Inhibitor of caspase-3, -7 and -9. Mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B.
  • 组织特异性Ubiquitous, except peripheral blood leukocytes.
  • 疾病相关Defects in XIAP are the cause of lymphoproliferative syndrome X-linked type 2 (XLP2) [MIM:300635]. XLP is a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus (EBV). Symptoms include severe or fatal mononucleosis, acquired hypogammaglobulinemia, pancytopenia and malignant lymphoma.
  • 序列相似性Belongs to the IAP family.
    Contains 3 BIR repeats.
    Contains 1 RING-type zinc finger.
  • 结构域The first BIR domain is involved in interaction with TAB1/MAP3K7IP1 and is important for dimerization. The second BIR domain is sufficient to inhibit caspase-3 and caspase-7, while the third BIR is involved in caspase-9 inhibition. The interactions with SMAC and PRSS25 are mediated by the second and third BIR domains.
  • 翻译后修饰Ubiquitinated and degraded by the proteasome in apoptotic cells.
    Phosphorylation by PKB/AKT protects XIAP against ubiquitination and protects the protein against proteasomal degradation.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AP 13 antibody
    • API3 antibody
    • Apoptosis Inhibitor 3 antibody
    • Baculoviral IAP repeat containing 4 antibody
    • Baculoviral IAP Repeat Containing Protein 4 antibody
    • Baculoviral IAP repeat-containing protein 4 antibody
    • BIRC 4 antibody
    • BIRC4 antibody
    • E3 ubiquitin-protein ligase XIAP antibody
    • hIAP-3 antibody
    • hIAP3 antibody
    • HILP antibody
    • IAP 3 antibody
    • IAP like protein antibody
    • IAP-3 antibody
    • IAP-like protein antibody
    • IAP3 antibody
    • ILP 1 antibody
    • ILP antibody
    • ILP1 antibody
    • Inhibitor of apoptosis protein 3 antibody
    • Inhibitor of Apoptosis X Linked antibody
    • Mammalian IAP Homologue A antibody
    • MIHA antibody
    • X linked IAP antibody
    • X linked inhibitor of apoptosis antibody
    • X linked inhibitor of apoptosis E3 ubiquitin protein ligase antibody
    • X linked inhibitor of apoptosis protein antibody
    • X-linked IAP antibody
    • X-linked inhibitor of apoptosis protein antibody
    • Xiap antibody
    • XIAP_HUMAN antibody
    • XLP2 antibody
    see all

Anti-XIAP antibody - N-terminal 图像

  • Anti-XIAP antibody - N-terminal (ab86229) at 1/100 dilution + Mouse liver tissue lysate at 12.5 µg

    Predicted band size : 57 kDa
  • Anti-XIAP antibody - N-terminal (ab86229) at 1/100 dilution + Ramos cell line lysate at 35 µg

    Predicted band size : 57 kDa
  • ab86229, at 1/50 dilution, staining XIAP in formalin-fixed, paraffin-embedded Human colon carcinoma by Immunohistochemistry, followed by peroxidase-conjugated secondary antibody and DAB staining.
  • ab86229, at 1/50 dilution, staining XIAP in formalin-fixed, paraffin-embedded Human colon carcinoma by Immunohistochemistry, followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-XIAP antibody - N-terminal (ab86229)参考文献

ab86229 has not yet been referenced specifically in any publications.

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