Anti-XBP1抗体(ab85546)
Key features and details
- Goat polyclonal to XBP1
- Suitable for: ELISA, IHC-P
- Reacts with: Mouse, Dog, Human
- Isotype: IgG
概述
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产品名称
Anti-XBP1抗体
参阅全部 XBP1 一抗 -
描述
山羊多克隆抗体to XBP1 -
宿主
Goat -
经测试应用
适用于: ELISA, IHC-Pmore details
不适用于: WB -
种属反应性
与反应: Mouse, Dog, Human
预测可用于: Chimpanzee, Gorilla -
免疫原
Synthetic peptide:
NHSWEDTFANELFPQ
by a Cysteine residue linker, corresponding to C terminal amino acids 358-372 of Human XBP1 isoform 2 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab85546于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
ELISA |
Use at an assay dependent concentration.
|
|
IHC-P | (4) |
Use a concentration of 5 µg/ml.
|
说明 |
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ELISA
Use at an assay dependent concentration. |
IHC-P
Use a concentration of 5 µg/ml. |
靶标
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功能
Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I. -
疾病相关
Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7) [MIM:612371]. Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature. -
序列相似性
Belongs to the bZIP family.
Contains 1 bZIP domain. -
细胞定位
Nucleus. - Information by UniProt
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数据库链接
- Entrez Gene: 7494 Human
- Entrez Gene: 22433 Mouse
- Omim: 194355 Human
- SwissProt: P17861 Human
- SwissProt: O35426 Mouse
- Unigene: 437638 Human
- Unigene: 469937 Mouse
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别名
- Tax responsive element binding protein 5 antibody
- Tax-responsive element-binding protein 5 antibody
- TREB5 antibody
see all
图片
数据表及文件
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Datasheet download
文献 (4)
ab85546 被引用在 4 文献中.
- Obert DP et al. ER stress preconditioning ameliorates liver damage after hemorrhagic shock and reperfusion. Exp Ther Med 21:248 (2021). PubMed: 33603856
- Pavlovic N et al. Inhibiting IRE1a-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma. Elife 9:N/A (2020). PubMed: 33103995
- Wolpert A et al. Hepatic topographical changes of endoplasmic reticulum stress and unfolded protein response signaling after hemorrhagic shock and reperfusion. J Surg Res 231:278-289 (2018). PubMed: 30278941
- Piret SE et al. A mouse model for inherited renal fibrosis associated with endoplasmic reticulum stress. Dis Model Mech 10:773-786 (2017). IHC-P ; Mouse . PubMed: 28325753