概述

  • 产品名称Anti-XBP1抗体
    参阅全部 XBP1 一抗
  • 描述
    小鼠单克隆抗体to XBP1
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human, Recombinant Fragment
  • 免疫原

    Recombinant XBP1 fragment (Human) (AAH12841, 123 a.a. ~ 225 a.a) with a tag.

  • 阳性对照
    • Hela NE cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab76443 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB 1/500 - 1/1000. Detects a band of approximately 40 kDa (predicted molecular weight: 29 kDa).

靶标

  • 功能Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I.
  • 疾病相关Genetic variations in XBP1 could be associated with susceptibility to major affective disorder type 7 (MAFD7) [MIM:612371]. Major affective disorders represent a class of mental disorders characterized by a disturbance in mood as their predominant feature.
  • 序列相似性Belongs to the bZIP family.
    Contains 1 bZIP domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Tax responsive element binding protein 5 antibody
    • Tax-responsive element-binding protein 5 antibody
    • TREB5 antibody
    • X box binding protein 1 antibody
    • X box binding protein 2 antibody
    • X-box-binding protein 1 antibody
    • XBP 1 antibody
    • XBP-1 antibody
    • XBP1 antibody
    • XBP1_HUMAN antibody
    • XBP2 antibody
    see all

Anti-XBP1 antibody 图像

  • Anti-XBP1 antibody (ab76443) at 1/500 dilution + Recombinant protein at 0.2 µg

    Secondary
    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/5000 dilution

    Predicted band size : 29 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
  • Anti-XBP1 antibody (ab76443) at 1/500 dilution + Hela NE cell lysate at 25 µg

    Secondary
    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

    Predicted band size : 29 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)

Anti-XBP1 antibody (ab76443)参考文献

ab76443 has not yet been referenced specifically in any publications.

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