Anti-Xanthine Oxidase抗体(ab125133)

概述

  • 产品名称Anti-Xanthine Oxidase抗体
    参阅全部 Xanthine Oxidase 一抗
  • 描述
    兔多克隆抗体to Xanthine Oxidase
  • 经测试应用适用于: WB, IP, IHC-Pmore details
  • 种属反应性
    与反应: Cow, Human
  • 免疫原

    Xanthine Oxidase purified from Cow Buttermilk.

  • 阳性对照
    • Human Liver tissue.

性能

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应用

Our Abpromise guarantee covers the use of ab125133 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 146 kDa.
IP 1/100.
IHC-P Use a concentration of 5 - 10 µg/ml.

靶标

  • 功能Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. Has also low oxidase activity towards aldehydes (in vitro).
  • 组织特异性Detected in milk (at protein level).
  • 疾病相关Defects in XDH are the cause of xanthinuria type 1 (XU1) [MIM:278300]. Xanthinuria is characterized by excretion of very large amounts of xanthine in the urine and a tendency to form xanthine stones. Uric acid is strikingly diminished in serum and urine. XU1 is due to isolated xanthine dehydrogenase. XU1 patients can metabolize allopurinol.
  • 序列相似性Belongs to the xanthine dehydrogenase family.
    Contains 1 2Fe-2S ferredoxin-type domain.
    Contains 1 FAD-binding PCMH-type domain.
  • 翻译后修饰Subject to partial proteolysis; this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O).
    Contains sulfhydryl groups that are easily oxidized (in vitro); this alters the enzyme from the dehydrogenase form (D) to the oxidase form (O).
  • 细胞定位Cytoplasm. Peroxisome. Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Xanthine dehydrogenase antibody
    • Xanthine dehydrogenase/oxidase antibody
    • Xanthine oxidase antibody
    • Xanthine oxidoreductase antibody
    • XD antibody
    • XDH antibody
    • XDH_HUMAN antibody
    • xdha antibody
    • XO antibody
    • xor antibody
    see all

Anti-Xanthine Oxidase antibody 图像

  • ab125133 at 5 µg/ml staining Xanthine Oxidase in formalin-fixed, paraffin-embedded Human liver tissue by Immunohistochemistry.

Anti-Xanthine Oxidase antibody (ab125133)参考文献

ab125133 has not yet been referenced specifically in any publications.

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