概述

  • 产品名称Anti-Wnt10a抗体
    参阅全部 Wnt10a 一抗
  • 描述
    兔多克隆抗体to Wnt10a
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Wnt10a (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).

  • 阳性对照
    • Human pancreatic islet tissue

性能

应用

Our Abpromise guarantee covers the use of ab62051 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use at an assay dependent concentration. PubMed: 23094073
IHC-P Use a concentration of 10 µg/ml.

靶标

  • 功能Ligand for members of the frizzled family of seven transmembrane receptors. Probable developmental protein. May be a signaling molecule important in CNS development. Is likely to signal over only few cell diameters.
  • 疾病相关Defects in WNT10A are a cause of ectodermal dysplasia anhidrotic (EDA) [MIM:224900]; also known ectodermal dysplasia hypohidrotic autosomal recessive (HED). Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDA is characterized by sparse hair (atrichosis or hypotrichosis), abnormal or missing teeth and the inability to sweat due to the absence of sweat glands. Note=Most patients carrying WNT10A mutations present with sweating anomalies. However, comparison with EDA cases harboring mutations in the ectodysplasin pathway identifies some phenotypic differences. Dermatological features (anomalies of hair and sweat glands) are less severe in patients carrying WNT10A mutations and facial dysmorphism can be absent. The dental phenotype consists in microdontia, whereas teeth agenesis is more frequent in patients carrying mutations in the ectodysplasin pathway.
    Defects in WNT10A are a cause of odonto-onycho-dermal dysplasia (OODD) [MIM:257980]. OODD is a rare autosomal recessive ectodermal dysplasia in which the presenting phenotype is dry hair, severe hypodontia, smooth tongue with marked reduction of fungiform and filiform papillae, onychodysplasia, keratoderma and hyperhidrosis of palms and soles, and hyperkeratosis of the skin.
    Defects in WNT10A are a cause of Schopf-Schulz-Passarge syndrome (SSPS) [MIM:224750]. SSPS is rare ectodermal dysplasia, characterized chiefly by cysts of the eyelid margins, palmoplantar keratoderma, hypodontia, hypotrichosis and nail dystrophy. Multiple eyelid apocrine hidrocystomas are the hallmark of this condition, although they usually appear in adulthood. The concomitant presence of eccrine syringofibroadenoma in most patients and of other adnexal skin tumors in some affected subjects indicates that Schopf-Schulz-Passarge syndrome is a genodermatosis with skin appendage neoplasms.
  • 序列相似性Belongs to the Wnt family.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ14301 antibody
    • OODD antibody
    • Protein Wnt-10a antibody
    • SSPS antibody
    • STHAG4 antibody
    • Wingless type MMTV integration site family member 10A antibody
    • WN10A_HUMAN antibody
    • wnt10a antibody
    see all

Anti-Wnt10a antibody 图像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human stomach tissue sections labelling Wnt10a with ab62051.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human prostate tissue sections labelling Wnt10a with ab62051.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human melanoma (lymph node) tissue sections labelling Wnt10a with ab62051.

  • ab62051, at 10µg/ml, staining Wnt10a in Formalin Fixed Paraffin Embedded Human Pancreatic Islets tissue by Immunohistochemistry.

Anti-Wnt10a antibody (ab62051)参考文献

This product has been referenced in:
  • Hayano S  et al. Roles of heparan sulfate sulfation in dentinogenesis. J Biol Chem 287:12217-29 (2012). WB, ICC/IF ; Mouse . Read more (PubMed: 22351753) »
  • Hsu RJ  et al. WNT10A Plays an Oncogenic Role in Renal Cell Carcinoma by Activating WNT/ß-catenin Pathway. PLoS One 7:e47649 (2012). WB, IHC-P ; Human . Read more (PubMed: 23094073) »

See all 2 Publications for this product

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