Anti-WIF1抗体(ab186845)
Key features and details
- Rabbit polyclonal to WIF1
- Suitable for: WB
- Reacts with: Mouse, Human
- Isotype: IgG
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
-
产品名称
Anti-WIF1抗体
参阅全部 WIF1 一抗 -
描述
兔多克隆抗体to WIF1 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Mouse, Human -
免疫原
Recombinant fragment within Human WIF1. The exact sequence is proprietary.
Database link: Q9Y5W5 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 49% PBS -
Concentration information loading...
-
纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
-
Related Products
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab186845于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/500 - 1/2000. Predicted molecular weight: 41 kDa.
|
说明 |
---|
WB
1/500 - 1/2000. Predicted molecular weight: 41 kDa. |
靶标
-
功能
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. -
序列相似性
Contains 5 EGF-like domains.
Contains 1 WIF domain. -
细胞定位
Secreted. - Information by UniProt
-
数据库链接
- Entrez Gene: 11197 Human
- Entrez Gene: 24117 Mouse
- Omim: 605186 Human
- SwissProt: Q9Y5W5 Human
- SwissProt: Q9WUA1 Mouse
- Unigene: 284122 Human
- Unigene: 32831 Mouse
-
别名
- WIF-1 antibody
- wif1 antibody
- WIF1_HUMAN antibody
- Wnt inhibitory factor 1 antibody
图片
实验方案
数据表及文件
-
SDS download
-
Datasheet download
文献 (9)
ab186845 被引用在 9 文献中.
- Tan W et al. Wnt inhibitory 1 ameliorates neovascularization and attenuates photoreceptor injury in an oxygen-induced retinopathy mouse model. Biofactors 48:683-698 (2022). PubMed: 35080047
- Zhang YF et al. Effects of propofol on colon cancer metastasis through STAT3/HOTAIR axis by activating WIF-1 and suppressing Wnt pathway. Cancer Med 9:1842-1854 (2020). PubMed: 31953926
- Praktiknjo SD et al. Tracing tumorigenesis in a solid tumor model at single-cell resolution. Nat Commun 11:991 (2020). PubMed: 32080185
- Farbehi N et al. Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury. Elife 8:N/A (2019). PubMed: 30912746
- Zhu J et al. Genistein inhibits invasion and migration of colon cancer cells by recovering WIF1 expression. Mol Med Rep 17:7265-7273 (2018). PubMed: 29568950
- Tang XB et al. Expression pattern of Wif1 andß-catenin during development of anorectum in fetal rats with anorectal malformations. PeerJ 6:e4445 (2018). PubMed: 29507836
- Lin B et al. c-Jun suppresses the expression of WNT inhibitory factor 1 through transcriptional regulation and interaction with DNA methyltransferase 1 in gallbladder cancer. Mol Med Rep 17:8180-8188 (2018). PubMed: 29693707
- Cai J et al. Simultaneous overactivation of Wnt/ß-catenin and TGFß signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC. Nat Commun 8:15870 (2017). PubMed: 28627514
- George L et al. Transcriptomic analysis comparing mouse strains with extreme total lung capacities identifies novel candidate genes for pulmonary function. Respir Res 18:152 (2017). IHC-P ; Mouse . PubMed: 28793908