概述

  • 产品名称
  • 描述
    兔多克隆抗体to WHSC2
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region between internal sequence amino acids 261-290 of Human WHSC2 (NP_005654.3)

  • 阳性对照
    • NCI-H460 cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab123674 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 57 kDa.

靶标

  • 功能
    Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. Probably required to interact with the RNA polymerase II complex.
  • 组织特异性
    Ubiquitous. Expressed in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. Expressed at lower level in adult lung. Expressed in fetal brain, lung, liver and kidney.
  • 序列相似性
    Belongs to the NELF-A family.
    Contains 1 HDAg-like domain.
  • 结构域
    The HDAg-like domain is essential for transcriptional repression, and mediates the interaction with the RNA polymerase II complex.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FLJ10442 antibody
    • FLJ25112 antibody
    • Negative elongation factor A antibody
    • Negative elongation factor polypeptide A antibody
    • NELF A antibody
    • NELF-A antibody
    • NELFA antibody
    • NELFA_HUMAN antibody
    • P/OKcl.15 antibody
    • P/OKcl15 antibody
    • WHSC 2 antibody
    • Whsc2 antibody
    • Wolf Hirschhorn syndrome candidate 2 antibody
    • Wolf Hirschhorn syndrome candidate 2 protein antibody
    • Wolf-Hirschhorn syndrome candidate 2 protein antibody
    see all

图片

  • Anti-WHSC2 antibody (ab123674) at 1/100 dilution + NCI-H460 cell lysate at 35 µg

    Predicted band size : 57 kDa

实验方案

文献

ab123674 has not yet been referenced specifically in any publications.

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