The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明IHC-P: 1/100 - 1/500.
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能Functions as a modulator for initiation or reinitiation events during DNA polymerase delta-mediated DNA synthesis. Has an intrinsic ATPase activity that functions as a sensor of DNA damage or of arrested replication forks and regulates the extent of DNA synthesis.
序列相似性Belongs to the AAA ATPase family. Contains 1 UBZ-type zinc finger.
翻译后修饰Sumoylated by SUMO1 and SUMO2/3.
细胞定位Nucleus. Colocalizes with WRN in granular structures in the nucleus.