概述

  • 产品名称Anti-WDR8抗体
    参阅全部 WDR8 一抗
  • 描述
    兔多克隆抗体to WDR8
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 146-195 (RYLALAERRD CRDYVSIFVC SDWQLLRHFD TDTQDLTGIE WAPNGCVLAA) of Mouse WDR8 (NP_067474.2).

  • 阳性对照
    • Mouse brain lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Constituents: 97% PBS, 2% Sucrose
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab116245 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 52 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology (PubMed:26545777). Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (PubMed:26675238).
  • 组织特异性Ubiquitous. Predominant expression in heart, brain, liver, thymus, prostate, and testis, and barely detectable expression in lung.
  • 序列相似性Contains 6 WD repeats.
  • 细胞定位Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite. Enriched in the proximal end of the mother centriole (PubMed:26545777). During ciliogenesis also associated with the basal body of the adjacent centriole (PubMed:26675238).
  • Information by UniProt
  • 数据库链接
  • 别名
    • Dd57 antibody
    • WD repeat domain 8 antibody
    • WD repeat-containing protein 8 antibody
    • WD repeat-containing protein antisense to TP73 gene antibody
    • WD repeat-containing protein WRAP73 antibody
    • WDR8 antibody
    • Wrap73 antibody
    • WRP73_HUMAN antibody
    see all

Anti-WDR8 antibody 图像

  • Anti-WDR8 antibody (ab116245) at 1 µg/ml + Mouse brain lysate at 10 µg

    Predicted band size : 52 kDa

Anti-WDR8 antibody (ab116245)参考文献

ab116245 has not yet been referenced specifically in any publications.

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