概述

  • 产品名称Anti-WDR77抗体
    参阅全部 WDR77 一抗
  • 描述
    兔多克隆抗体to WDR77
  • 经测试应用适用于: IHC-P, IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Guinea pig, Cow, Dog, Chimpanzee, Ferret, Rhesus monkey, Gorilla, Orangutan, Elephant
  • 免疫原

    Synthetic peptide within Human WDR77 aa 1-50. The exact sequence is proprietary.
    Database link: NP_077007.1

  • 阳性对照
    • HeLa whole cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab80616 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/1000 - 1/5000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
IP Use at 2-5 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Non-catalytic component of the 20S PRMT5-containing methyltransferase complex, which modifies specific arginines to dimethylarginines in several spliceosomal Sm proteins. This modification targets Sm proteins to the survival of motor neurons (SMN) complex for assembly into small nuclear ribonucleoprotein core particles. Might play a role in transcription regulation. The 20S PRMT5-containing methyltransferase complex also methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage.
    • 组织特异性Highly expressed in heart, skeletal muscle, spleen, testis, uterus, prostate and thymus. In testis, expressed in germ cells and Leydig cells, but not in peritubular myocytes, nor in Sertoli cells. Expressed in prostate cancers, in seminomas and in Leydig cell tumors.
    • 序列相似性Contains 5 WD repeats.
    • 发展阶段Expressed in Leydig cells during fetal testicular development, especially during the second semester. Germ cells expression is detected as early as 10 weeks of gestation.
    • 细胞定位Nucleus. Cytoplasm. Nuclear in Leydig cells and cytoplasmic in germ cells during fetal testicular development. In adult testis, predominantly nuclear. Subcellular location varies from nuclear to cytoplasmic in various tumors.
    • Information by UniProt
    • 数据库链接
    • 别名
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      • HKMT1069 antibody
      • MEP 50 antibody
      • MEP-50 antibody
      • MEP50 antibody
      • MEP50_HUMAN antibody
      • Methylosome protein 50 antibody
      • MGC2722 antibody
      • Nbla10071 antibody
      • p44 antibody
      • p44/Mep50 antibody
      • RGD1310479 antibody
      • RP11 552M11.3 antibody
      • WD repeat containing protein 77 antibody
      • WD repeat domain 77 antibody
      • WD repeat-containing protein 77 antibody
      • WDR77 antibody
      see all

    Anti-WDR77 antibody 图像

    • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human pancreatic islet cell tumor tissue labelling WDR77 with ab80616 at 1/5000 (0.2µg/ml). Detection: DAB.

    Anti-WDR77 antibody (ab80616)参考文献

    ab80616 has not yet been referenced specifically in any publications.

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