概述

  • 产品名称
  • 描述
    兔多克隆抗体to WDR58
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Guinea pig, Cow, Cat, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within internal sequence amino acids 144-193 (AGGDCQLHTM DLETGTFTRV LRGHTDYIHC LALRERSPEV LSGGEDGAVR) of human WDR58 (NP_077315).

  • 阳性对照
    • Human fetal pancreas lysate

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: None
    Constituents: 2% Sucrose, PBS
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Purified by peptide affinity chromatography method.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab84900 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能
    Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and THOC4.
  • 序列相似性
    Belongs to the WD repeat THOC6 family.
    Contains 7 WD repeats.
  • Information by UniProt
  • 数据库链接
  • 别名
    • fSAP35 antibody
    • Functional spliceosome-associated protein 35 antibody
    • MGC2655 antibody
    • PSEC0006 antibody
    • THO complex 6 homolog antibody
    • THO complex subunit 6 homolog antibody
    • Thoc6 antibody
    • THOC6_HUMAN antibody
    • WD repeat containing protein 58 antibody
    • WD repeat domain 58 antibody
    • WD repeat-containing protein 58 antibody
    see all

图片

  • Anti-WDR58 antibody (ab84900) at 1 µg/ml (in 5% skim milk / PBS buffer) + human fetal pancreas lysate at 10 µg

    Secondary
    HRP conjugated anti-Rabbit IgG at 1/50000 dilution

    Predicted band size : 38 kDa
    Observed band size : 38 kDa

实验方案

文献

ab84900 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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