概述

  • 产品名称Anti-WDR51A抗体
    参阅全部 WDR51A 一抗
  • 描述
    小鼠多克隆抗体to WDR51A
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein of Human WDR51A

  • 阳性对照
    • Transfected 293T cells.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 纯度Protein A purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab67698 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 40 kDa (predicted molecular weight: 45 kDa).

靶标

  • 功能Involved in early steps of centriole duplication, as well as in the later steps of centriole length control. Required for ciliogenesis.
  • 疾病相关Defects in POC1A are the cause of short stature, onychodysplasia, facial dysmorphism, and hypotrichosis (SOFT) [MIM:614813]. A syndrome characterized by severely short long bones, peculiar facies associated with paucity of hair, and nail anomalies. Growth retardation is evident on prenatal ultrasound as early as the second trimester of pregnancy, and affected individuals reach a final stature consistent with a height age of 6 years to 8 years. Relative macrocephaly is present during early childhood but head circumference is markedly low by adulthood. Psychomotor development is normal. Facial dysmorphism includes a long, triangular face with prominent nose and small ears, and affected individuals have an unusual high-pitched voice. Clinodactyly, brachydactyly, and hypoplastic distal phalanges and fingernails are present in association with postpubertal sparse and short hair. Typical skeletal findings include short and thick long bones with mild irregular metaphyseal changes, short femoral necks, and hypoplastic pelvis and sacrum. All long bones of the hand are short, with major delay of carpal ossification and cone-shaped epiphyses. Vertebral body ossification is also delayed. Note=Cells derived from affected individuals have abnormal mitotic mechanics with multipolar spindles, in addition to clearly impaired ciliogenesis.
  • 序列相似性Belongs to the WD repeat POC1 family.
    Contains 7 WD repeats.
  • 细胞定位Cytoplasm > cytoskeleton > centrosome > centriole. Cytoplasm > cytoskeleton > cilium basal body. Component of both mother and daughter centrioles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Pix2 antibody
    • POC1 centriolar protein homolog A (Chlamydomonas) antibody
    • POC1 centriolar protein homolog A antibody
    • Poc1a antibody
    • POC1A_HUMAN antibody
    • WD repeat containing protein 51A antibody
    • WD repeat domain 51A antibody
    • WD repeat-containing protein 51A antibody
    see all

Anti-WDR51A antibody 图像

  • All lanes : Anti-WDR51A antibody (ab67698) at 1/500 dilution

    Lane 1 : WDR51A transfected 293T cells lysate
    Lane 2 : non transfected lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 45 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)

Anti-WDR51A antibody (ab67698)参考文献

ab67698 has not yet been referenced specifically in any publications.

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