概述

  • 产品名称Anti-WDR5抗体
    参阅全部 WDR5 一抗
  • 描述
    兔多克隆抗体to WDR5
  • 特异性This antibody does not cross react with other nuclear proteins or DNA binding proteins.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Rat, Human, Arabidopsis thaliana
    预测可用于: Chicken, Cow, Dog, Pig, Xenopus laevis, Zebrafish
  • 免疫原

    Synthetic peptide: DVKTGKCLKTLPAHSDPV, corresponding to amino acids 157-174 of Human WDR5

性能

应用

Our Abpromise guarantee covers the use of ab75439 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500. Predicted molecular weight: 37 kDa.
ELISA 1/10000.

靶标

  • 功能Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.
  • 序列相似性Belongs to the WD repeat WDR5/wds family.
    Contains 7 WD repeats.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
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Anti-WDR5 antibody (ab75439)参考文献

This product has been referenced in:
  • Le Douce V  et al. LSD1 cooperates with CTIP2 to promote HIV-1 transcriptional silencing. Nucleic Acids Res 40:1904-15 (2012). ChIP . Read more (PubMed: 22067449) »
  • Ding Y  et al. ATX1-generated H3K4me3 is required for efficient elongation of transcription, not initiation, at ATX1-regulated genes. PLoS Genet 8:e1003111 (2012). ChIP ; Arabidopsis thaliana . Read more (PubMed: 23284292) »

See all 3 Publications for this product

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