Anti-WAVE 1 (phospho Y125)抗体(ab59280)

概述

  • 产品名称Anti-WAVE 1 (phospho Y125)抗体
    参阅全部 WAVE 1 一抗
  • 描述
    兔多克隆抗体to WAVE 1 (phospho Y125)
  • 特异性Detects endogenous levels of WAVE1 only when phosphorylated at tyrosine 125.
  • 经测试应用适用于: ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic phosphopeptide derived from human WAVE1 around the phosphorylation site of tyrosine 125 (E-T-YP-D-V).

  • 阳性对照
    • Human colon carcinoma.

性能

应用

Our Abpromise guarantee covers the use of ab59280 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/5000.
IHC-P Use at an assay dependent concentration.

靶标

  • 功能Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.
  • 组织特异性Highly expressed in brain. Lowly expressed in testis, ovary, colon, kidney, pancreas, thymus, small intestine and peripheral blood.
  • 序列相似性Belongs to the SCAR/WAVE family.
    Contains 1 WH2 domain.
  • 结构域Binds the Arp2/3 complex through the C-terminal region and actin through verprolin homology (VPH) domain.
  • 细胞定位Cytoplasm > cytoskeleton. Dot-like pattern in the cytoplasm. Concentrated in Rac-regulated membrane-ruffling areas.
  • Information by UniProt
  • 数据库链接
  • 别名
    • WASP family, verprolin homology domain-containing protein 1 antibody
    • WASP family member 1 antibody
    • FLJ31482 antibody
    • homology of dictyostelium scar 1 antibody
    • KIAA0269 antibody
    • Protein WAVE-1 antibody
    • Protein WAVE1 antibody
    • scar, Dictyostelium, homology of, 1 antibody
    • SCAR1 antibody
    • Similar to a plant extensin like protein antibody
    • Verprolin homology domain containing protein 1 antibody
    • Verprolin homology domain-containing protein 1 antibody
    • WAS protein family, member 1 antibody
    • Wasf1 antibody
    • WASF1_HUMAN antibody
    • WASL antibody
    • WASP family 1 antibody
    • WASP family protein member 1 antibody
    • WASP family, verprolin homology domain-containing protein antibody
    • WAVE antibody
    • WAVE1 antibody
    • Wiskott Aldrich syndrome protein family member 1 antibody
    • Wiskott-Aldrich syndrome protein family member 1 antibody
    see all

Anti-WAVE 1 (phospho Y125) antibody 图像

  • Ab59280 at 1/50 dilution staining human colon carcinoma without (left) and with (right) immunizing peptide; paraffin embedded.

Anti-WAVE 1 (phospho Y125) antibody (ab59280)参考文献

ab59280 has not yet been referenced specifically in any publications.

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