概述

  • 产品名称
    VU0155041
  • 描述
    PAM for mGluR4
  • 生物学描述
    Positive allosteric selective modulator at mGluR4 (EC50 values are 798 and 693 nM at human and rat mGluR4 receptors, respectively). It has advantages over PHCCC (ab120043) as it is more potent. Shows limited blood-brain barrier permeability. Active in behavioural models of Parkinson's disease following icv injection. Available in water-soluble form - please see VU0155041 sodium salt (ab120248).
  • 纯度
    > 99%

性能

文献

This product has been referenced in:
  • Niswender CM  et al. Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol 74:1345-58 (2008). Read more (PubMed: 18664603) »

See 1 Publication for this product

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