Anti-VR1抗体(ab21533)

概述

  • 产品名称Anti-VR1抗体
    参阅全部 VR1 一抗
  • 描述
    兔多克隆抗体to VR1
  • 特异性Recognises with high level of specificity Vanilloid receptor 1. The anatomical distribution corresponds to the known capsaicin receptor distribution within nociceptive neurons.
  • 经测试应用适用于: IHC-Frmore details
  • 种属反应性
    与反应: Rat
  • 免疫原

    Synthetic peptide:

    CYFSHLKEYVAS

    conjugated to KLH, corresponding to amino acids 529-540 of Rat Vanilloid Receptor 1.

  • 阳性对照
    • Rat dorsal root ganglia and spinal cord.

性能

应用

Our Abpromise guarantee covers the use of ab21533 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr Use at an assay dependent concentration.

靶标

  • 功能Receptor-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. May be involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accubens by affecting AMPA receptors endocytosis.
  • 组织特异性Widely expressed at low levels. Expression is elevated in dorsal root ganglia. In skin, expressed in cutaneous sensory nerve fibers, mast cells, epidermal keratinocytes, dermal blood vessels, the inner root sheet and the infundibulum of hair follicles, differentiated sebocytes, sweat gland ducts, and the secretory portion of eccrine sweat glands (at protein level).
  • 序列相似性Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.
    Contains 6 ANK repeats.
  • 结构域The association domain (AD) is necessary for self-association.
  • 翻译后修饰Phosphorylation by PKA reverses capsaicin-induced dephosphorylation at multiple sites, probably including Ser-117 as a major phosphorylation site. Phoshphorylation by CAMKII seems to regulate binding to vanilloids. Phosphorylated and modulated by PKCM and probably PKCZ. Dephosphorylation by calcineurin seems to lead to receptor desensitization and phosphorylation by CAMKII recovers activity.
  • 细胞定位Cell junction > synapse > postsynaptic cell membrane. Cell projection > dendritic spine membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Capsaicin receptor antibody
    • DKFZp434K0220 antibody
    • osm 9 like TRP channel 1 antibody
    • Osm-9-like TRP channel 1 antibody
    • OTRPC1 antibody
    • Transient receptor potential cation channel subfamily V member 1 antibody
    • TRPV 1 antibody
    • Trpv1 antibody
    • TRPV1_HUMAN antibody
    • Vanilloid receptor 1 antibody
    • Vanilloid receptor subtype 1 antibody
    • VR 1 antibody
    • VR1 antibody
    see all

Anti-VR1 antibody 图像

  • Immunohistochemical staining of Vanilloid Receptor 1 in rat dorsal root ganglia frozen section .

Anti-VR1 antibody (ab21533)参考文献

ab21533 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your reply, and I apologize again for the error on our datasheet. I am sending a free of charge vial of ab2723 on the order ***, which should arrive shortly. Please keep me updated about the results of this replacement ant...

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