Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
Belongs to the VPS37 family. Contains 1 VPS37 C-terminal domain.
Late endosome membrane. Probably associates with membranes. Recruited to the plasma membrane by HIV-1.