The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/50 - 1/200. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
1/250 - 1/500.
功能Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.
组织特异性Widely expressed. Expressed in macrophages and lymphocytes.
序列相似性Belongs to the VPS37 family. Contains 1 VPS37 C-terminal domain.
细胞定位Late endosome membrane. Recruited to the endosomal membrane in a VPS4A-dependent fashion.