概述

  • 产品名称Anti-VPS36抗体
    参阅全部 VPS36 一抗
  • 描述
    小鼠多克隆抗体to VPS36
  • 特异性This antibody is reactive against mammalian transfected lysate.
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length VPS36 protein (Human)

  • 阳性对照
    • VPS36 transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab67801 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: 1/500 - 1/1000. Detects a band of approximately 44 kDa (predicted molecular weight: 44 kDa).
    Detection Antibody Pair.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
    • 序列相似性Belongs to the VPS36 family.
      Contains 1 GLUE C-terminal domain.
      Contains 1 GLUE N-terminal domain.
    • 结构域The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates binding to ubiquitin and phosphoinosides.
    • 细胞定位Cytoplasm. Endosome. Late endosome. Membrane. Nucleus. Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
    • Information by UniProt
    • 数据库链接
    • 别名
      • C13orf9 antibody
      • CGI 145 antibody
      • EAP45 antibody
      • ELL associated protein of 45 kDa antibody
      • ELL-associated protein of 45 kDa antibody
      • ESCRT-II complex subunit VPS36 antibody
      • Vacuolar protein sorting associated protein 36 antibody
      • Vacuolar protein-sorting-associated protein 36 antibody
      • Vps36 antibody
      • VPS36_HUMAN antibody
      see all

    Anti-VPS36 antibody 图像

    • All lanes : Anti-VPS36 antibody (ab67801) at 1/500 dilution

      Lane 1 : VPS36 transfected 293T cell lysate
      Lane 2 : Non transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 44 kDa
      Observed band size : 44 kDa

    Anti-VPS36 antibody (ab67801)参考文献

    ab67801 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab67801.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"