概述

  • 产品名称Anti-VPS36抗体
    参阅全部 VPS36 一抗
  • 描述
    兔多克隆抗体to VPS36
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse
    预测可用于: Rat, Rabbit, Horse, Chicken, Guinea pig, Cow, Cat, Dog, Human, Zebrafish
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 91-140 (SNKEPGPFQS SKNSYIRLSF KEHGQIEFYR RLSEEMTQRR WETVPVSQSL) of Mouse VPS36 (NP_081614).

  • 阳性对照
    • Mouse liver lysate

性能

应用

Our Abpromise guarantee covers the use of ab125715 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
  • 序列相似性Belongs to the VPS36 family.
    Contains 1 GLUE C-terminal domain.
    Contains 1 GLUE N-terminal domain.
  • 结构域The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates binding to ubiquitin and phosphoinosides.
  • 细胞定位Cytoplasm. Endosome. Late endosome. Membrane. Nucleus. Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C13orf9 antibody
    • CGI 145 antibody
    • EAP45 antibody
    • ELL associated protein of 45 kDa antibody
    • ELL-associated protein of 45 kDa antibody
    • ESCRT-II complex subunit VPS36 antibody
    • Vacuolar protein sorting associated protein 36 antibody
    • Vacuolar protein-sorting-associated protein 36 antibody
    • Vps36 antibody
    • VPS36_HUMAN antibody
    see all

Anti-VPS36 antibody 图像

  • Anti-VPS36 antibody (ab125715) at 1 µg/ml + Mouse liver lysate at 10 µg

    Predicted band size : 44 kDa

Anti-VPS36 antibody (ab125715)参考文献

ab125715 has not yet been referenced specifically in any publications.

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