概述

  • 产品名称Anti-VPS36抗体
    参阅全部 VPS36 一抗
  • 描述
    兔多克隆抗体to VPS36
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Zebrafish
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 120-278 of Human VPS36 (AAH37279).

  • 阳性对照
    • NT2D1 whole cell lysate; IMR32, U87-MG, MCF-7 cell lysates

性能

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应用

Our Abpromise guarantee covers the use of ab101379 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 44 kDa.

靶标

  • 功能Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3.
  • 序列相似性Belongs to the VPS36 family.
    Contains 1 GLUE C-terminal domain.
    Contains 1 GLUE N-terminal domain.
  • 结构域The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates binding to ubiquitin and phosphoinosides.
  • 细胞定位Cytoplasm. Endosome. Late endosome. Membrane. Nucleus. Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation.
  • Information by UniProt
  • 数据库链接
  • 别名
    • C13orf9 antibody
    • CGI 145 antibody
    • EAP45 antibody
    • ELL associated protein of 45 kDa antibody
    • ELL-associated protein of 45 kDa antibody
    • ESCRT-II complex subunit VPS36 antibody
    • Vacuolar protein sorting associated protein 36 antibody
    • Vacuolar protein-sorting-associated protein 36 antibody
    • Vps36 antibody
    • VPS36_HUMAN antibody
    see all

Anti-VPS36 antibody 图像

  • Anti-VPS36 antibody (ab101379) at 1/1000 dilution + NT2D1 whole cell lysate at 30 µg

    Predicted band size : 44 kDa

Anti-VPS36 antibody (ab101379)参考文献

ab101379 has not yet been referenced specifically in any publications.

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