Anti-VPS36抗体(ab101379)
Key features and details
- Rabbit polyclonal to VPS36
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-VPS36抗体
参阅全部 VPS36 一抗 -
描述
兔多克隆抗体to VPS36 -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat, Cow, Zebrafish -
免疫原
Recombinant fragment, corresponding to a region within amino acids 120-278 of Human VPS36 (AAH37279).
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阳性对照
- NT2D1 whole cell lysate; IMR32, U87-MG, MCF-7 cell lysates
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
存储溶液
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 1.21% Tris, 0.75% Glycine, 20% Glycerol (glycerin, glycerine) -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Positive Controls
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab101379于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/500 - 1/3000. Predicted molecular weight: 44 kDa.
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说明 |
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WB
1/500 - 1/3000. Predicted molecular weight: 44 kDa. |
靶标
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功能
Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. -
序列相似性
Belongs to the VPS36 family.
Contains 1 GLUE C-terminal domain.
Contains 1 GLUE N-terminal domain. -
结构域
The GLUE domain (GRAM-like ubiquitin-binding in EAP45) mediates binding to ubiquitin and phosphoinosides. -
细胞定位
Cytoplasm. Endosome. Late endosome. Membrane. Nucleus. Colocalizes with ubiquitinated proteins on late endosomes. Recruited to the endosome membrane to participate in vesicle formation. - Information by UniProt
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数据库链接
- Entrez Gene: 511223 Cow
- Entrez Gene: 51028 Human
- Entrez Gene: 70160 Mouse
- Entrez Gene: 290851 Rat
- Entrez Gene: 335810 Zebrafish
- Omim: 610903 Human
- SwissProt: A5PK00 Cow
- SwissProt: Q86VN1 Human
see all -
别名
- C13orf9 antibody
- CGI 145 antibody
- EAP45 antibody
see all
图片
数据表及文件
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SDS download
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Datasheet download
文献 (0)
ab101379 尚未被引用在任何文献中。