Anti-Von Willebrand Factor抗体[36B11] (ab49706)

概述

  • 产品名称Anti-Von Willebrand Factor抗体[36B11]
    参阅全部 Von Willebrand Factor 一抗
  • 描述
    小鼠单克隆抗体[36B11] to Von Willebrand Factor
  • 经测试应用适用于: IHC-Fr, IHC-Pmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fusion protein corresponding to the A2 domain of the von Willebrand factor.

  • 阳性对照
    • Human tonsil tissue

性能

应用

Our Abpromise guarantee covers the use of ab49706 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-Fr 1/100 - 1/200. Acetone fixation recommended.
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
    • 组织特异性Plasma.
    • 疾病相关Defects in VWF are the cause of von Willebrand disease (VWD) [MIM:277480]. VWD defines a group of hemorrhagic disorders in which the von Willebrand factor is either quantitatively or qualitatively abnormal resulting in altered platelet function. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII and impaired platelet adhesion. Type I von Willebrand disease is the most common form and is characterized by partial quantitative plasmatic deficiency of an otherwise structurally and functionally normal Willebrand factor; type II is associated with a qualitative deficiency and functional anomalies of the Willebrand factor; type III is the most severe form and is characterized by total or near-total absence of Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII.
    • 序列相似性Contains 1 CTCK (C-terminal cystine knot-like) domain.
      Contains 4 TIL (trypsin inhibitory-like) domains.
      Contains 3 VWFA domains.
      Contains 3 VWFC domains.
      Contains 4 VWFD domains.
    • 结构域The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.
    • 翻译后修饰All cysteine residues are involved in intrachain or interchain disulfide bonds.
      N- and O-glycosylated.
    • 细胞定位Secreted. Secreted > extracellular space > extracellular matrix. Localized to storage granules.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Coagulation factor VIII antibody
      • Coagulation factor VIII VWF antibody
      • F8VWF antibody
      • Factor VIII related antigen antibody
      • von Willebrand antigen 2 antibody
      • von Willebrand antigen II antibody
      • Von Willebrand disease antibody
      • VWD antibody
      • vWF antibody
      • VWF_HUMAN antibody
      see all

    Anti-Von Willebrand Factor antibody [36B11] (ab49706)参考文献

    This product has been referenced in:
    • Vishnubalaji R  et al. In vitro differentiation of human skin-derived multipotent stromal cells into putative endothelial-like cells. BMC Dev Biol 12:7 (2012). ICC/IF ; Human . Read more (PubMed: 22280443) »

    See 1 Publication for this product

    Product Wall

    Vielen Dank für Ihren Anruf.

    Nachdem ich wie versprochen alle unsere Von Willebrand Faktor- Antikörperdaraufhin untersucht habe, ob sie möglicherweise die Bindung von Faktor VIII inhibieren können, weiß ich nicht, ob...

    Read More

    Thank you for contacting us.

    I am looking into adding the VW33-5 clone to our catalogue, and will e-mail you when I find out if it is available. The other clone, N10, is described in the paper at the following link. I think this must be the ...

    Read More

    Thank you for contacting Abcam.

    I wish to apologize for the delay in getting this information about ananti-Von Willebrand antibody which is specific to human and has less than 10% mouse cross reactivity.

    I have gone through each o...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"