Anti-Von Willebrand Factor抗体[2Q2134] (ab68545)


  • 产品名称Anti-Von Willebrand Factor抗体[2Q2134]
    参阅全部 Von Willebrand Factor 一抗
  • 描述
    小鼠单克隆抗体[2Q2134] to Von Willebrand Factor
  • 特异性ab68545 reacts strongly with human von Willebrand Factor in both plasma and tissues.
  • 经测试应用适用于: IP, IHC-P, RIA, IHC-Fr, ICC/IF, ELISAmore details
  • 种属反应性
    与反应: Human, Pig
  • 免疫原

    Full length protein (Human)



Our Abpromise guarantee covers the use of ab68545 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent concentration.
IHC-P Use at an assay dependent concentration. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
RIA Use at an assay dependent concentration.
IHC-Fr Use at an assay dependent concentration.
ICC/IF Use at an assay dependent concentration. For Indirect Immunoperoxidase staining: Use at 1/50 dilution.
ELISA Use at an assay dependent concentration.


  • 功能Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma.
  • 组织特异性Plasma.
  • 疾病相关Defects in VWF are the cause of von Willebrand disease (VWD) [MIM:277480]. VWD defines a group of hemorrhagic disorders in which the von Willebrand factor is either quantitatively or qualitatively abnormal resulting in altered platelet function. Symptoms vary depending on severity and disease type but may include prolonged bleeding time, deficiency of factor VIII and impaired platelet adhesion. Type I von Willebrand disease is the most common form and is characterized by partial quantitative plasmatic deficiency of an otherwise structurally and functionally normal Willebrand factor; type II is associated with a qualitative deficiency and functional anomalies of the Willebrand factor; type III is the most severe form and is characterized by total or near-total absence of Willebrand factor in the plasma and cellular compartments, also leading to a profound deficiency of plasmatic factor VIII.
  • 序列相似性Contains 1 CTCK (C-terminal cystine knot-like) domain.
    Contains 4 TIL (trypsin inhibitory-like) domains.
    Contains 3 VWFA domains.
    Contains 3 VWFC domains.
    Contains 4 VWFD domains.
  • 结构域The von Willebrand antigen 2 is required for multimerization of vWF and for its targeting to storage granules.
  • 翻译后修饰All cysteine residues are involved in intrachain or interchain disulfide bonds.
    N- and O-glycosylated.
  • 细胞定位Secreted. Secreted > extracellular space > extracellular matrix. Localized to storage granules.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Coagulation factor VIII antibody
    • Coagulation factor VIII VWF antibody
    • F8VWF antibody
    • Factor VIII related antigen antibody
    • von Willebrand antigen 2 antibody
    • von Willebrand antigen II antibody
    • Von Willebrand disease antibody
    • VWD antibody
    • vWF antibody
    • VWF_HUMAN antibody
    see all

Anti-Von Willebrand Factor antibody [2Q2134] (ab68545)参考文献

This product has been referenced in:
  • Balaoing LR  et al. Laminin Peptide-Immobilized Hydrogels Modulate Valve Endothelial Cell Hemostatic Regulation. PLoS One 10:e0130749 (2015). IF ; Human . Read more (PubMed: 26090873) »
  • Chen D  et al. Curcumin accelerates reendothelialization and ameliorates intimal hyperplasia in balloon-injured rat carotid artery via the upregulation of endothelial cell autophagy. Int J Mol Med 36:1563-71 (2015). Read more (PubMed: 26459716) »

See all 6 Publications for this product

Product Wall

Thank you for contacting us.

There is very little epitope information about any of the Von Willebrand Factor antibodies; because of this few have been identified as recognizing the N-terminus of vWF. Some of them may recognize the N-term,...

Read More

Vielen Dank für Ihren Anruf.

Wie versprochen habe ich bezüglich des Von Willebrand FactorAntikörpers ab11713 im Labor nachgefragt. Ich kann Ihnen nun bestätigen, dass dieser Antikörper spezifisch für den Von Will...

Read More

Thank you for your call today and for your questions about our VWF antibodies.
As we discussed, ab68545 would be a good antibody to try in sandwich ELISA with ab6994. I have issued a discount code that is worth 1 free primary antibody after submit...

Read More

Thank you for getting back to me and for gathering more information about the customer's assay.

I have conducted some search for your customer and found some products which might be suitable for this application. However, it is important to e...

Read More
Abcam has not validated the combination of species/application used in this Abreview.
Application Immunocytochemistry/ Immunofluorescence
Sample Mouse Cell (lung tissue)
Specification lung tissue
Fixative Formaldehyde
Permeabilization No
Blocking step No blocking step used for 1 hour(s) and 0 minute(s)

Abcam user community

Verified customer

提交于 Jun 17 2011