Anti-Vitamin D Receptor (phospho S51)抗体(ab79311)

概述

  • 产品名称Anti-Vitamin D Receptor (phospho S51)抗体
    参阅全部 Vitamin D Receptor 一抗
  • 描述
    兔多克隆抗体to Vitamin D Receptor (phospho S51)
  • 特异性ab79311 detects endogenous levels of Vitamin D3 Receptor only when phosphorylated at serine 51.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthesized phosphopeptide derived from human Vitamin D3 Receptor around the phosphorylation site of serine 51 (R-R-SP-M-K).

  • 阳性对照
    • COLO cell extract treated with insulin (0.01U/ml for 15mins).

性能

应用

Our Abpromise guarantee covers the use of ab79311 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 38 kDa (predicted molecular weight: 48 kDa).
ELISA 1/20000.

靶标

  • 功能Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
  • 疾病相关Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1 25 dihydroxyvitamin D3 receptor antibody
    • 1 antibody
    • 1,25 dihydroxyvitamin D3 receptor antibody
    • 1,25-@dihydroxyvitamin D3 receptor antibody
    • 25-dihydroxyvitamin D3 receptor antibody
    • Member 1 antibody
    • NR1I1 antibody
    • Nuclear receptor subfamily 1 group I member 1 antibody
    • PPP1R163 antibody
    • Protein phosphatase 1, regulatory subunit 163 antibody
    • VDR antibody
    • VDR_HUMAN antibody
    • Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody
    • Vitamin D hormone receptor antibody
    • Vitamin D nuclear receptor variant 1 antibody
    • Vitamin D receptor antibody
    • Vitamin D3 receptor antibody
    see all

Anti-Vitamin D Receptor (phospho S51) antibody 图像

  • All lanes : Anti-Vitamin D Receptor (phospho S51) antibody (ab79311) at 1/500 dilution

    Lane 1 : COLO cells extract treated with insulin (0.01U/ml, 15mins)
    Lane 2 : COLO cells extract treated with insulin (0.01U/ml, 15mins) with Immunizing phosphopeptide at 5 µg

    Lysates/proteins at 5 µg per lane.


    Predicted band size : 48 kDa
    Observed band size : 38 kDa (why is the actual band size different from the predicted?)

Anti-Vitamin D Receptor (phospho S51) antibody (ab79311)参考文献

ab79311 has not yet been referenced specifically in any publications.

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