Vitamin D Receptor肽(288-299) (ab45748)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列CGNQDYKYRVSD
    • 氨基酸288 to 299

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45748 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Vitamin D Receptor antibody (ab39990)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • 1
    • 1 25 dihydroxyvitamin D3 receptor
    • 1,25 dihydroxyvitamin D3 receptor
    • 1,25-@dihydroxyvitamin D3 receptor
    • 25-dihydroxyvitamin D3 receptor
    • Member 1
    • NR1I1
    • Nuclear receptor subfamily 1 group I member 1
    • PPP1R163
    • Protein phosphatase 1, regulatory subunit 163
    • VDR
    • VDR_HUMAN
    • Vitamin D (1,25- dihydroxyvitamin D3) receptor
    • Vitamin D hormone receptor
    • Vitamin D nuclear receptor variant 1
    • Vitamin D receptor
    • Vitamin D3 receptor
    see all
  • 功能Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
  • 疾病相关Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt

Vitamin D Receptor peptide (288-299) (ab45748)参考文献

ab45748 has not yet been referenced specifically in any publications.

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