Vitamin D Receptor肽(288-299) (ab45748)

概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      CGNQDYKYRVSD
    • 氨基酸
      288 to 299

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45748 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Vitamin D Receptor antibody (ab39990)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • 1
    • 1 25 dihydroxyvitamin D3 receptor
    • 1,25 dihydroxyvitamin D3 receptor
    • 1,25-@dihydroxyvitamin D3 receptor
    • 25-dihydroxyvitamin D3 receptor
    • Member 1
    • NR1I1
    • Nuclear receptor subfamily 1 group I member 1
    • PPP1R163
    • Protein phosphatase 1, regulatory subunit 163
    • VDR
    • VDR_HUMAN
    • Vitamin D (1,25- dihydroxyvitamin D3) receptor
    • Vitamin D hormone receptor
    • Vitamin D nuclear receptor variant 1
    • Vitamin D receptor
    • Vitamin D3 receptor
    see all
  • 功能
    Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
  • 疾病相关
    Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.
  • 序列相似性
    Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域
    Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 细胞定位
    Nucleus.
  • Information by UniProt

Vitamin D Receptor peptide (288-299) (ab45748)参考文献

ab45748 has not yet been referenced specifically in any publications.

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