Anti-Vitamin D Receptor抗体(ab61781)

概述

  • 产品名称Anti-Vitamin D Receptor抗体
    参阅全部 Vitamin D Receptor 一抗
  • 描述
    兔多克隆抗体to Vitamin D Receptor
  • 经测试应用适用于: ICC/IF, WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic non phosphopeptide derived from Vitamin D Receptor (Human) around the phosphorylation site of serine 208 (DLSpEE).

  • 阳性对照
    • Extracts from Jurkat cells, HeLa cells.

性能

应用

Our Abpromise guarantee covers the use of ab61781 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF
WB
ELISA
  • 应用说明ELISA: 1/10000.
    ICC/IF: 1/500 - 1/1000.
    WB: 1/500 - 1/1000. Detects bands of approximately 30 and 48 kDa (predicted molecular weight: 48 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
    • 疾病相关Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.
    • 序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • 结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 1 25 dihydroxyvitamin D3 receptor antibody
      • 1 antibody
      • 1,25 dihydroxyvitamin D3 receptor antibody
      • 1,25-@dihydroxyvitamin D3 receptor antibody
      • 25-dihydroxyvitamin D3 receptor antibody
      • Member 1 antibody
      • NR1I1 antibody
      • Nuclear receptor subfamily 1 group I member 1 antibody
      • PPP1R163 antibody
      • Protein phosphatase 1, regulatory subunit 163 antibody
      • VDR antibody
      • VDR_HUMAN antibody
      • Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody
      • Vitamin D hormone receptor antibody
      • Vitamin D nuclear receptor variant 1 antibody
      • Vitamin D receptor antibody
      • Vitamin D3 receptor antibody
      see all

    Anti-Vitamin D Receptor antibody 图像

    • Immunofluorescence analysis of HeLa cells, using ab61781 antibody at 1/500 dilution in the presence and absence of the immunizing peptide
    • All lanes : Anti-Vitamin D Receptor antibody (ab61781) at 1/500 dilution

      Lane 1 : extracts from Jurkat cells
      Lane 2 : extracts from Jurkat cells with immunizing peptide


      Predicted band size : 48 kDa
      Observed band size : 48 kDa
      Additional bands at : 30 kDa (possible cross reactivity).

    Anti-Vitamin D Receptor antibody (ab61781)参考文献

    ab61781 has not yet been referenced specifically in any publications.

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