Anti-Vitamin D Receptor抗体(ab115495)


  • 产品名称Anti-Vitamin D Receptor抗体
    参阅全部 Vitamin D Receptor 一抗
  • 描述
    大鼠单克隆抗体to Vitamin D Receptor
  • 特异性ab115495 recognizes both the occupied and unoccupied forms of Vitamin D Recptor. It does not cross-react with estrogen and glucocorticoid receptors. In mammals, recognizes a protein of ~53kD which is identified as Vitamin D Receptor (VDR). In avians, VDR appears as a doublet of 58 and 60kD.
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Chicken, Hamster, Human, Pig, Xenopus laevis, Fish
  • 免疫原

    Vitamin D Receptor protein from Chicken intestine

  • 表位Amino acids 89-105
  • 阳性对照
    • Human Colon tissue




Our Abpromise guarantee covers the use of ab115495 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
EMSA Use at an assay dependent concentration.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 51 kDa.
IHC-P Use a concentration of 10 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • 功能Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.
  • 疾病相关Defects in VDR are the cause of rickets vitamin D-dependent type 2A (VDDR2A) [MIM:277440]. A disorder of vitamin D metabolism resulting in severe rickets, hypocalcemia and secondary hyperparathyroidism. Most patients have total alopecia in addition to rickets.
  • 序列相似性Belongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • 结构域Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1 25 dihydroxyvitamin D3 receptor antibody
    • 1 antibody
    • 1,25 dihydroxyvitamin D3 receptor antibody
    • 1,25-@dihydroxyvitamin D3 receptor antibody
    • 25-dihydroxyvitamin D3 receptor antibody
    • Member 1 antibody
    • NR1I1 antibody
    • Nuclear receptor subfamily 1 group I member 1 antibody
    • PPP1R163 antibody
    • Protein phosphatase 1, regulatory subunit 163 antibody
    • VDR antibody
    • VDR_HUMAN antibody
    • Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody
    • Vitamin D hormone receptor antibody
    • Vitamin D nuclear receptor variant 1 antibody
    • Vitamin D receptor antibody
    • Vitamin D3 receptor antibody
    see all

Anti-Vitamin D Receptor antibody 图像

  • ab115495, at 10 µg/ml, staining Vitamin D Receptor in formalin-fixed, paraffin-embedded Human Colon tissue by Immunohistochemistry using a biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-Vitamin D Receptor antibody (ab115495)参考文献

ab115495 has not yet been referenced specifically in any publications.

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