Anti-Viral Protein U抗体(ab81532)

概述

  • 产品名称Anti-Viral Protein U抗体
  • 描述
    兔多克隆抗体to Viral Protein U
  • 经测试应用适用于: ELISA, WB, ICC/IF, IPmore details
  • 种属反应性
    Reacts with HIV1.
  • 免疫原

    Synthetic peptide:

    EGDQEELSALMEMGHHAPWNVND

    , corresponding to amino acids 58-80 of Viral Protein U, post-synthetically modified to achieve highest antigenicity and coupled to KLH using heterobifunctional cross linker.

性能

应用

Our Abpromise guarantee covers the use of ab81532 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/50000.
WB 1/1000. Positive for Cells transfected with Vpu
ICC/IF 1/250.
IP 1/250.

靶标

  • 相关性Retroviruses have several characteristic structural and catalytic proteins. One such auxiliary protein is a viral protein U (Vpu) which enhances virion release from human cells and is also involved in the degradation of CD4, the cellular surface receptor of HIV-1. The Vpu has no homolog in less pathogenic HIV-2 virus. Vpu is an 81 amino acid class I membrane integral protein that is unique to human and simian immunodeficiency virus isolated from Chimpanzee and a few other monkey species. The 16kDa protein Vpu protein consists of an N-terminal hydrophobic membrane anchor of 27 amino acids and a charged C-terminal hydrophilic domain of 54 amino acids that extents to the cytoplasm. The cytoplasmic domain has a conserved dual serine phosphorylation site (S52 GXX and S56 motif) that is phosphorylated by casein kinase II. Vpu is involved in viral replication and degradation of its cellular receptor CD4 and enhancement of viral particle release from macrophages and primary lymphocytes.
  • 细胞定位Membrane; Single-pass type I membrane protein.
  • 别名
    • U ORF protein antibody
    • Vpu antibody

Anti-Viral Protein U antibody (ab81532)参考文献

ab81532 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab81532.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"