概述

  • 产品名称Anti-VGLUT3抗体
    参阅全部 VGLUT3 一抗
  • 描述
    兔多克隆抗体to VGLUT3
  • 特异性Antiserum to rat VGLUT3 reacts specifically with 60-62 kD protein of BON cells stably expressing VGLUT3 and of total rat brain extracts. No reactivity was detected with VGLUT1 and VGLUT2.
  • 经测试应用适用于: WB, Electron Microscopy, ICC/IFmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    A 16 residue synthetic peptide derived from C terminal domain of rat Vesicular Glutamate Transporter type 3 (VGLUT3).

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: None.
    Constituents: 50% Glycerol, Whole serum.
  • 纯度Whole antiserum
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab23977 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
Electron Microscopy
ICC/IF
  • 应用说明Electron Microscopy: 1/5000.
    ICC/IF: 1/200.
    WB: 1/2000. Predicted molecular weight: 65 kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Mediates the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells. May also mediate the transport of inorganic phosphate.
    • 组织特异性Expressed in amygdala, cerebellum, hippocampus, medulla, spinal cord and thalamus.
    • 疾病相关Defects in SLC17A8 are the cause of deafness autosomal dominant type 25 (DFNA25) [MIM:605583]. DFNA25 is a form of sensorineural hearing loss. The expression of DFNA25 deafness is variable in terms of onset and rate of progression, with an age-dependent penetrance resembling an early-onset presbycusis, or senile deafness, a progressive bilateral loss of hearing that occurs in the aged.
    • 序列相似性Belongs to the major facilitator superfamily. Sodium/anion cotransporter family. VGLUT subfamily.
    • 细胞定位Cytoplasmic vesicle > secretory vesicle > synaptic vesicle membrane. Membrane. Cell junction > synapse > synaptosome.
    • Information by UniProt
    • 数据库链接
    • 别名
      • deafness autosomal dominant 25 antibody
      • DFNA 25 antibody
      • DFNA25 antibody
      • SLC17A8 antibody
      • Solute carrier family 17 (sodium dependent inorganic phosphate cotransporter) member 8 antibody
      • Solute carrier family 17 member 8 antibody
      • Vesicular glutamate transporter 3 antibody
      • VGLU3_HUMAN antibody
      • VGLUT 3 antibody
      • VGluT3 antibody
      see all

    Anti-VGLUT3 antibody (ab23977)参考文献

    This product has been referenced in:
    • Munguba GC  et al. Vesicular glutamate transporter 3 in age-dependent optic neuropathy. Mol Vis 17:413-9 (2011). WB ; Mouse . Read more (PubMed: 21311743) »
    • Cheng XR  et al. Expression of VGLUTs contributes to degeneration and acquisition of learning and memory. Neurobiol Learn Mem 95:361-75 (2011). Read more (PubMed: 21295146) »

    See all 2 Publications for this product

    Product Wall

    Application Immunocytochemistry/ Immunofluorescence
    Sample Mouse Cell (neuron)
    Specification neuron
    Fixative Paraformaldehyde
    Blocking step Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5%
    Username

    Emily Lowry

    Verified customer

    提交于 Aug 11 2006

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"