The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Vesicle docking protein p115 antibody (ab40822)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
General vesicular transport factor
General vesicular transport factor p115
Protein USO1 homolog
Transcytosis associated protein
Vesicle docking protein
功能General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity.
序列相似性Belongs to the VDP/USO1/EDE1 family. Contains 10 ARM repeats.
结构域Composed of a globular head, an elongated tail (coiled-coil) and a highly acidic C-terminal domain.
翻译后修饰Phosphorylated in a cell cycle-specific manner; phosphorylated in interphase but not in mitotic cells. Dephosphorylated protein associates with the Golgi membrane; phosphorylation promotes dissociation.
细胞定位Cytoplasm > cytosol. Golgi apparatus membrane. Recycles between the cytosol and the Golgi apparatus during interphase. During interphase, the phosphorylated form is found exclusively in cytosol; the unphosphorylated form is associated with Golgi apparatus membranes.