Venlafaxine hydrochloride (ab120715)

概述

  • 产品名称Venlafaxine hydrochloride
  • 描述
    Serotonin-norepinephrine reuptake inhibitor
  • 别名
    • Wy 54030
  • 生物学描述Serotonin-norepinephrine reuptake inhibitor. Ki values are 82 and 2480 nM for SERT and NET, respectively. Displays 30-fold higher affinity for SERT than NET in vitro. Antidepressant.
  • 纯度> 99%
  • 常规说明

    This product is reported to be light sensitive

性能

    应用

    Our Abpromise guarantee covers the use of ab120715 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    应用 Ab评论 说明
    Functional Studies Use at an assay dependent concentration.

    Venlafaxine hydrochloride 图像

    • ab18207 staining beta III tubulin in PC-12 cells treated with venlafaxine hydrochloride (ab120715), by ICC/IF. Increase in the number and length of neurites (stained with beta III tubulin) correlates with increased concentration of venlafaxine hydrochloride, as described in literature.
      The NGF treated cells were incubated at 37°C for 6 hour in media containing different concentrations of ab120715 (venlafaxine hydrochloride) in DMSO, fixed with 4% formaldehyde for 10 minutes at room temperature and blocked with PBS containing 10% goat serum, 0.3 M glycine, 1% BSA and 0.1% tween for 2h at room temperature. Staining of the treated cells with ab18207 (1 µg/ml) was performed overnight at 4°C in PBS containing 1% BSA and 0.1% tween. A DyLight 488 anti-rabbit polyclonal antibody (ab96899) at 1/250 dilution was used as the secondary antibody.

    Venlafaxine hydrochloride (ab120715)参考文献

    This product has been referenced in:
    • Yilmaz N  et al. Effects of venlafaxine and escitalopram treatments on NMDA receptors in the rat depression model. J Membr Biol 242:145-51 (2011). Read more (PubMed: 21755298) »
    • Bymaster FP  et al. Comparative affinity of duloxetine and venlafaxine for serotonin and norepinephrine transporters in vitro and in vivo, human serotonin receptor subtypes, and other neuronal receptors. Neuropsychopharmacology 25:871-80 (2001). Read more (PubMed: 11750180) »

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