概述

  • 产品名称
    Anti-VEGFR 1+VEGFR 2抗体
  • 描述
    兔多克隆抗体to VEGFR 1+VEGFR 2
  • 宿主
    Rabbit
  • 特异性
    This antibody is specific for VEGFR 1 with significant cross-reactivity with the VEGFR 2 protein.
  • 经测试应用
    适用于: WB, ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Synthetic peptide corresponding to Mouse VEGFR 1+VEGFR 2 aa 800-900.
    Sequence:

    PDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGK VVQASAFG IKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGAC TK

    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
  • 阳性对照
    • HUVEC lysate

应用

Our Abpromise guarantee covers the use of ab36844 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/2000. Predicted molecular weight: 150 kDa.
ICC/IF 1/500.
IHC-P 1/250 - 1/500.

靶标

  • 相关性
    Receptors for VEGF, VEGFB and PGF have a tyrosine-protein kinase activity. The VEGF-kinase ligand/receptor signaling system plays a key role in vascular development and regulation of vascular permeability. VEGF and its high-affinity binding receptors, the tyrosine kinases FLK1 and FLT1, are thought to be important for the development of embryonic vasculature. It has been shown that an alternately spliced form of FLT1 produces a soluble protein, termed sFLT1, which binds vascular endothelial growth factor with high affinity, playing an inhibitory role in angiogenesis.
  • 细胞定位
    Cell Membrane
  • 数据库链接
    see all
  • 别名
    • FLK1 antibody
    • FLT1 antibody
    • KDR antibody
    • Kinase insert domain receptor antibody
    • Vascular endothelial growth factor receptor 1 antibody
    • Vascular endothelial growth factor receptor 2 antibody
    • Vascular permeability factor receptor antibody
    • VEGFR antibody
    • VEGFR1 antibody
    see all

图片

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEGFR 1+VEGFR 2 antibody (ab36844)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEGFR 1+VEGFR 2 antibody (ab36844)

    IHC analysis of a formalin-fixed paraffin-embedded (FFPE) human breast carcinoma tissue section using 1:500 dilution of ab36844. The assay involved 20 minutes of heat induced antigen retrieval (HIER) with 10mM sodium citrate buffer (pH 6.0) and endogenous peroxidase quenching using peroxide block. The sections were incubated with primary antibody for 30 minutes.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEGFR 1+VEGFR 2 antibody (ab36844)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-VEGFR 1+VEGFR 2 antibody (ab36844)

    IHC analysis of a formalin-fixed paraffin-embedded (FFPE) human breast carcinoma tissue section using 1:500 dilution of ab36844. The assay involved 20 minutes of heat induced antigen retrieval (HIER) with 10mM sodium citrate buffer (pH 6.0) and endogenous peroxidase quenching using peroxide block. The sections were incubated with primary antibody for 30 minutes.

实验方案

文献

This product has been referenced in:
  • Song W  et al. Quercetin inhibits angiogenesis-mediated human retinoblastoma growth by targeting vascular endothelial growth factor receptor. Oncol Lett 14:3343-3348 (2017). Read more (PubMed: 28927086) »
  • Nusrat O  et al. The Role of Angiogenesis in the Persistence of Chemoresistance in Epithelial Ovarian Cancer. Reprod Sci 23:1484-1492 (2016). Read more (PubMed: 27122375) »

See all 3 Publications for this product

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