概述

  • 产品名称Anti-VEGFD抗体[28AT743.288.48]
    参阅全部 VEGFD 一抗
  • 描述
    小鼠单克隆抗体[28AT743.288.48] to VEGFD
  • 经测试应用适用于: ICC/IF, ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    Three KLH-conjugated synthetic peptides corresponding to N-terminal, central, and C-terminal sequences of human VEGF4.

  • 阳性对照
    • HDMEC cell lysates

性能

应用

Our Abpromise guarantee covers the use of ab38687 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent dilution. PubMed: 20827282
ELISA 1/1000.
WB 1/100 - 1/500. Predicted molecular weight: 40 kDa.

靶标

  • 功能Growth factor active in angiogenesis, lymphangiogenesis and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in the formation of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors.
  • 组织特异性Highly expressed in lung, heart, small intestine and fetal lung, and at lower levels in skeletal muscle, colon, and pancreas.
  • 序列相似性Belongs to the PDGF/VEGF growth factor family.
  • 翻译后修饰Undergoes a complex proteolytic maturation which generates a variety of processed secreted forms with increased activity toward VEGFR-3 and VEGFR-2. VEGF-D first form an antiparallel homodimer linked by disulfide bonds before secretion. The fully processed VEGF-D is composed mostly of two VEGF homology domains (VHDs) bound by non-covalent interactions.
  • 细胞定位Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • c-fos induced growth factor antibody
    • c-fos induced growth factor (vascular endothelial growth factor D) antibody
    • c-fos induced growth factor antibody
    • c-fos-induced growth factor antibody
    • FIGF antibody
    • Vascular endothelial growth factor D antibody
    • Vascular endothelial growth factor D precursor antibody
    • Vascular endothelial growth factor D precursor antibody
    • VEGF D antibody
    • VEGF-D antibody
    • VEGFD antibody
    • VEGFD_HUMAN antibody
    see all

Anti-VEGFD antibody [28AT743.288.48] 图像

Anti-VEGFD antibody [28AT743.288.48] (ab38687)参考文献

This product has been referenced in:
  • Moussai D  et al. The human cutaneous squamous cell carcinoma microenvironment is characterized by increased lymphatic density and enhanced expression of macrophage-derived VEGF-C. J Invest Dermatol 131:229-36 (2011). ICC/IF ; Human . Read more (PubMed: 20827282) »

See 1 Publication for this product

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